:root {
  --bg: #f7f8f7;
  --panel: #ffffff;
  --ink: #151817;
  --muted: #64706b;
  --line: #dfe5e1;
  --accent: #126b5b;
  --accent-2: #b14b36;
  --cds: #126b5b;
  --exon: #9eb6ae;
  --utr: #d9a441;
  --sequence-font: ui-monospace, SFMono-Regular, Menlo, Consolas, "Liberation Mono", monospace;
}

* {
  box-sizing: border-box;
}

body {
  margin: 0;
  background: var(--bg);
  color: var(--ink);
  font-family: Inter, ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
  font-size: 16px;
  line-height: 1.5;
}

.shell {
  width: min(1180px, calc(100% - 32px));
  margin: 32px auto;
}

.hidden {
  display: none !important;
}

.top-nav {
  position: sticky;
  top: 0;
  z-index: 20;
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 24px;
  min-height: 68px;
  padding: 10px max(24px, calc((100vw - 1180px) / 2 + 16px));
  border-bottom: 1px solid var(--line);
  background: rgba(247, 248, 247, .94);
  backdrop-filter: blur(12px);
}

.nav-brand {
  display: grid;
  justify-items: start;
  gap: 1px;
  height: auto;
  padding: 0;
  border-radius: 0;
  background: transparent;
  color: var(--ink);
  text-align: left;
}

.brand-mark {
  font-size: 22px;
  font-weight: 850;
  line-height: 1;
  letter-spacing: 0;
}

.brand-sub {
  color: var(--muted);
  font-size: 12px;
  font-weight: 650;
  text-transform: uppercase;
  letter-spacing: .08em;
}

.nav-menu {
  display: flex;
  align-items: stretch;
  gap: 4px;
}

.nav-link {
  height: 42px;
  padding: 0 13px;
  border-radius: 6px;
  background: transparent;
  color: var(--ink);
  font-size: 15px;
}

.nav-anchor {
  display: inline-flex;
  align-items: center;
  text-decoration: none;
}

.nav-link:hover,
.nav-dropdown:focus-within > .nav-link,
.nav-dropdown:hover > .nav-link,
.nav-brand:hover {
  background: #e9eeeb;
}

.nav-dropdown {
  position: relative;
}

.nav-dropdown::after {
  content: "";
  position: absolute;
  top: 100%;
  right: 0;
  display: none;
  width: 100%;
  height: 10px;
}

.nav-dropdown:hover::after,
.nav-dropdown:focus-within::after {
  display: block;
}

.dropdown-menu {
  position: absolute;
  top: calc(100% + 8px);
  right: 0;
  display: none;
  min-width: 190px;
  padding: 6px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--panel);
  box-shadow: 0 14px 36px rgba(21, 24, 23, .12);
}

.nav-dropdown:hover .dropdown-menu,
.nav-dropdown:focus-within .dropdown-menu {
  display: grid;
  gap: 3px;
}

.dropdown-menu button {
  justify-content: flex-start;
  width: 100%;
  height: 36px;
  padding: 0 10px;
  background: transparent;
  color: var(--ink);
  text-align: left;
  font-size: 14px;
}

.dropdown-menu button:hover:not(:disabled) {
  background: #edf5f2;
  color: var(--accent);
}

.dropdown-menu button:disabled {
  color: var(--muted);
  cursor: default;
  opacity: .7;
}

.about-view {
  display: grid;
  gap: 18px;
}

.about-panel {
  display: grid;
  gap: 12px;
  min-width: 0;
  padding: 24px 26px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--panel);
}

.about-panel h2 {
  margin: 10px 0 0;
  font-size: 22px;
  letter-spacing: 0;
}

.about-panel h2:first-child {
  margin-top: 0;
}

.about-panel p {
  max-width: none;
  margin: 0;
  font-size: 16px;
  line-height: 1.7;
  overflow-wrap: anywhere;
}

.about-panel a {
  color: var(--accent);
  font-weight: 650;
  text-decoration: underline;
  text-underline-offset: 3px;
}

.about-disclaimer {
  padding: 14px 16px;
  border: 1px solid #d9a441;
  border-left: 5px solid #d9a441;
  border-radius: 8px;
  background: #fffaf0;
  color: var(--muted);
}

.about-disclaimer strong {
  color: var(--ink);
}

.source-list {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 12px;
  width: 100%;
  max-width: none;
  margin-top: 2px;
  min-width: 0;
}

.source-list article {
  display: grid;
  gap: 7px;
  align-content: start;
  min-width: 0;
  padding: 14px 16px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfcfb;
}

.source-list h3 {
  margin: 0;
  color: var(--accent);
  font-size: 15px;
  letter-spacing: 0;
}

.source-list p {
  max-width: none;
  font-size: 14.5px;
  line-height: 1.58;
  overflow-wrap: anywhere;
}

.team-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 12px;
  width: 100%;
  max-width: none;
  margin-top: 2px;
  min-width: 0;
}

.team-card {
  display: grid;
  gap: 10px;
  align-items: start;
  min-width: 0;
  padding: 16px 17px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfcfb;
}

.team-role {
  display: flex;
  align-items: center;
  height: 20px;
  color: var(--accent);
  font-size: 13px;
  font-weight: 850;
  letter-spacing: .08em;
  line-height: 1.35;
  text-transform: uppercase;
}

.team-card h3 {
  margin: 0;
  color: var(--ink);
  font-size: 17px;
  font-weight: 850;
  line-height: 1.3;
  letter-spacing: 0;
}

.team-card p {
  margin: 0;
  color: var(--muted);
  font-size: 14.5px;
  font-weight: 500;
  line-height: 1.55;
  overflow-wrap: anywhere;
}

.team-people {
  display: grid;
  gap: 14px;
}

.team-person {
  display: grid;
  gap: 3px;
}

.team-card-supervisors {
  grid-column: 1 / -1;
}

.team-card-supervisors .team-people {
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 14px;
  padding: 12px 0 2px;
  border-top: 1px solid var(--line);
  border-bottom: 1px solid var(--line);
}

.team-card .team-affiliation {
  color: var(--muted);
  font-size: 12.5px;
  font-weight: 500;
  line-height: 1.35;
}

.team-degree {
  color: var(--muted);
  font-size: 12.5px;
  font-weight: 650;
  white-space: nowrap;
}

.team-description {
  margin-top: 0 !important;
}

.supervisor-description {
  margin-top: 2px !important;
}

.quick-nav {
  position: fixed;
  right: 22px;
  bottom: 22px;
  z-index: 30;
  display: grid;
  gap: 8px;
}

.quick-nav button {
  width: 84px;
  height: 36px;
  border: 1px solid var(--line);
  border-radius: 999px;
  background: rgba(255, 255, 255, .94);
  color: var(--ink);
  box-shadow: 0 10px 28px rgba(21, 24, 23, .12);
  font-size: 13px;
}

.quick-nav button:hover {
  border-color: var(--accent);
  color: var(--accent);
  background: #fbfcfb;
}

.home-view {
  min-height: calc(100vh - 110px);
  display: grid;
  place-items: center;
  align-content: center;
  gap: 24px;
}

.home-head {
  width: min(1120px, 100%);
  text-align: center;
}

.brand-line {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  gap: 14px;
  flex-wrap: wrap;
}

.home-head h1 {
  font-size: 54px;
}

.beta-badge {
  display: inline-flex;
  align-items: center;
  height: 28px;
  border: 1px solid var(--line);
  border-radius: 999px;
  padding: 0 11px;
  background: #fbfcfb;
  color: var(--accent);
  font-size: 13px;
  font-weight: 780;
  text-transform: uppercase;
  letter-spacing: .08em;
}

.home-intro {
  max-width: 1120px;
  margin: 12px auto 0;
  color: var(--muted);
  font-size: 17px;
  line-height: 1.58;
}

.home-intro a {
  color: var(--accent);
  font-weight: 650;
  text-decoration: underline;
  text-underline-offset: 3px;
}

.home-tools {
  width: min(1120px, 100%);
  display: grid;
  grid-template-columns: minmax(320px, 1.05fr) minmax(470px, 1.55fr);
  gap: 16px;
  align-items: stretch;
}

.home-photo {
  position: relative;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--panel);
  overflow: hidden;
  min-height: 456px;
}

.home-photo::after {
  content: "";
  position: absolute;
  inset: 0;
  background: linear-gradient(
    180deg,
    rgba(255, 255, 255, .10),
    rgba(255, 255, 255, .04)
  );
  pointer-events: none;
}

.home-photo img {
  width: 100%;
  height: 100%;
  object-fit: cover;
  object-position: 48% center;
  filter: saturate(.88) contrast(.92) brightness(.96);
}

.photo-credit {
  position: absolute;
  right: 10px;
  bottom: 8px;
  z-index: 1;
  padding: 3px 7px;
  border-radius: 4px;
  background: rgba(21, 24, 23, .58);
  color: rgba(255, 255, 255, .92);
  font-size: 10.5px;
  font-weight: 650;
  line-height: 1.2;
}

.tool-list {
  display: grid;
  grid-template-columns: minmax(210px, .95fr) minmax(230px, 1.05fr);
  grid-template-rows: auto auto;
  gap: 14px;
}

.tool-group-browse {
  grid-column: 1;
  grid-row: 1;
}

.tool-group-search {
  grid-column: 1;
  grid-row: 2;
}

.tool-group-analyze {
  grid-column: 2;
  grid-row: 1 / span 2;
}

.tool-group {
  display: grid;
  align-content: stretch;
  gap: 10px;
}

.tool-group h2 {
  margin: 0;
  color: var(--muted);
  font-size: 13px;
  font-weight: 850;
  letter-spacing: .08em;
  text-transform: uppercase;
}

.tool-card {
  display: grid;
  grid-template-columns: 44px minmax(0, 1fr);
  align-items: center;
  gap: 12px;
  min-height: 100px;
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 13px 14px;
  color: var(--ink);
  background: var(--panel);
  text-align: left;
  line-height: 1.2;
  cursor: pointer;
  transition: border-color .15s ease, transform .15s ease, background .15s ease;
}

.tool-card:hover {
  border-color: var(--accent);
  background: #fbfcfb;
  transform: translateX(2px);
}

.tool-card strong {
  display: block;
  color: var(--ink);
  font-size: 18px;
  font-weight: 780;
}

.tool-card small {
  display: block;
  margin-top: 5px;
  color: var(--muted);
  font-size: 14px;
  line-height: 1.35;
}

.resources-view {
  display: grid;
  gap: 18px;
}

.resources-panel {
  display: grid;
  gap: 12px;
  width: min(1040px, 100%);
  padding: 28px 30px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--panel);
}

.resources-panel h2 {
  margin: 12px 0 0;
  color: var(--ink);
  font-size: 22px;
  letter-spacing: 0;
}

.resources-panel h2:first-child {
  margin-top: 0;
}

.resources-panel p {
  margin: 0;
  color: var(--muted);
  font-size: 16px;
  line-height: 1.7;
}

.resources-panel a {
  color: var(--accent);
  font-weight: 650;
  text-decoration: underline;
  text-underline-offset: 3px;
}

.resource-link-list {
  display: grid;
  gap: 7px;
  margin: 0;
  padding-left: 20px;
}

.resource-link-list li {
  color: var(--muted);
  font-size: 15.5px;
  line-height: 1.55;
}

.resource-link-list li span {
  display: block;
  margin-top: 2px;
  color: var(--muted);
  font-size: 13.5px;
  line-height: 1.4;
}

.tile-icon {
  position: relative;
  display: grid;
  place-items: center;
  width: 42px;
  height: 42px;
  border: 1px solid var(--line);
  border-radius: 999px;
  color: var(--accent);
  font-size: 26px;
  line-height: 1;
  overflow: hidden;
}

.search-icon::before {
  content: "";
  width: 16px;
  height: 16px;
  border: 3px solid currentColor;
  border-radius: 999px;
  transform: translate(-3px, -3px);
}

.search-icon::after {
  content: "";
  position: absolute;
  width: 14px;
  height: 3px;
  border-radius: 999px;
  background: currentColor;
  transform: translate(9px, 10px) rotate(45deg);
}

.similar-icon::before,
.similar-icon::after {
  content: "";
  position: absolute;
  width: 22px;
  height: 12px;
  border: 3px solid currentColor;
  border-left: 0;
  border-radius: 0 999px 999px 0;
}

.similar-icon::before {
  transform: translate(-6px, -5px) rotate(180deg);
}

.similar-icon::after {
  transform: translate(6px, 5px);
}

.guide-icon::before {
  content: "";
  position: absolute;
  width: 23px;
  height: 3px;
  border-radius: 999px;
  background: currentColor;
  box-shadow: 0 7px 0 currentColor, 0 -7px 0 #8fc1a9;
  transform: translateX(-1px);
}

.guide-icon::after {
  content: "";
  position: absolute;
  right: 10px;
  top: 11px;
  width: 7px;
  height: 7px;
  border-top: 3px solid #d9a441;
  border-right: 3px solid #d9a441;
  transform: rotate(45deg);
}

.primer-icon::before,
.primer-icon::after {
  content: "";
  position: absolute;
}

.primer-icon::before {
  width: 27px;
  height: 3px;
  border-radius: 999px;
  background: currentColor;
  box-shadow: 0 10px 0 currentColor;
  transform: translateY(-5px);
}

.primer-icon::after {
  width: 9px;
  height: 9px;
  border-right: 3px solid #d9a441;
  border-bottom: 3px solid #d9a441;
  transform: translate(7px, 0) rotate(-45deg);
}

.blast-icon::before,
.blast-icon::after {
  content: "";
  position: absolute;
}

.blast-icon::before {
  width: 25px;
  height: 16px;
  border-left: 3px solid currentColor;
  border-bottom: 3px solid currentColor;
  transform: translate(-2px, 1px) skewX(-14deg);
}

.blast-icon::after {
  width: 20px;
  height: 3px;
  border-radius: 999px;
  background: #d9a441;
  box-shadow: 0 -7px 0 currentColor, 0 7px 0 #8fc1a9;
  transform: translate(4px, -1px);
}

.function-icon::before,
.function-icon::after {
  content: "";
  position: absolute;
  border-radius: 999px;
  background: currentColor;
}

.function-icon::before {
  width: 8px;
  height: 8px;
  box-shadow:
    -11px 10px 0 currentColor,
    11px 10px 0 currentColor,
    0 -12px 0 #d9a441;
}

.function-icon::after {
  width: 27px;
  height: 3px;
  background: #8fc1a9;
  box-shadow:
    0 12px 0 #8fc1a9,
    0 -12px 0 #8fc1a9;
  transform: rotate(28deg);
}

.genome-icon::before,
.genome-icon::after {
  content: "";
  position: absolute;
}

.genome-icon::before {
  width: 29px;
  height: 18px;
  border-top: 3px solid currentColor;
  border-bottom: 3px solid #d9a441;
  transform: skewX(-14deg);
}

.genome-icon::after {
  width: 28px;
  height: 3px;
  background: #8fc1a9;
  box-shadow: 0 8px 0 currentColor, 0 16px 0 #8fc1a9;
}

.prioritizer-icon::before,
.prioritizer-icon::after {
  content: "";
  position: absolute;
}

.prioritizer-icon::before {
  width: 26px;
  height: 22px;
  border-left: 3px solid currentColor;
  border-bottom: 3px solid currentColor;
}

.prioritizer-icon::after {
  width: 7px;
  height: 7px;
  border-radius: 999px;
  background: #d9a441;
  box-shadow: 9px -7px 0 var(--accent), 18px -14px 0 #8fc1a9;
}

.tile-title {
  font-size: 24px;
  font-weight: 750;
  letter-spacing: 0;
}

.tile-note {
  color: var(--muted);
  font-size: 15px;
}

.beta-notice {
  width: min(1120px, 100%);
  padding: 18px 20px;
  border: 1px solid #d9a441;
  border-left: 5px solid #d9a441;
  border-radius: 8px;
  background: #fffaf0;
  color: var(--ink);
}

.beta-notice strong {
  display: block;
  margin-bottom: 6px;
  font-size: 18px;
}

.beta-notice ul {
  display: grid;
  gap: 6px;
  margin: 0;
  padding-left: 18px;
}

.beta-notice li {
  color: var(--muted);
  font-size: 14.5px;
  line-height: 1.45;
}

.beta-notice li strong {
  display: inline;
  margin: 0;
  color: var(--ink);
  font-size: inherit;
}

.backHome {
  margin-bottom: 16px;
}

.module-head {
  padding-bottom: 18px;
  border-bottom: 1px solid var(--line);
}

.module-head h1 {
  font-size: 46px;
}

.similar-workflow {
  display: grid;
  gap: 18px;
}

.similar-form {
  display: grid;
  gap: 10px;
  padding: 18px 0;
}

.similar-form textarea {
  width: 100%;
  min-height: 116px;
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 12px 14px;
  background: var(--panel);
  color: var(--ink);
  font: 16px ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
  resize: vertical;
}

.guide-workflow {
  display: grid;
  gap: 18px;
}

.functional-workflow {
  display: grid;
  gap: 18px;
}

.prioritizer-workflow {
  display: grid;
  gap: 18px;
}

.primer-workflow {
  display: grid;
  gap: 18px;
}

.primer-form {
  padding: 18px 0;
}

.primer-grid {
  display: grid;
  grid-template-columns: minmax(0, 1fr) 360px;
  gap: 18px;
  align-items: stretch;
}

.primer-input-panel,
.primer-options-panel {
  display: grid;
  gap: 14px;
  align-content: start;
  min-height: 386px;
  padding: 18px 20px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--panel);
}

.primer-input-panel {
  grid-template-rows: auto auto 1fr;
}

.primer-sequence-wrap textarea {
  min-height: 244px;
}

.parameter-row {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 10px;
}

.primer-result-card {
  display: grid;
  gap: 14px;
}

.blast-workflow {
  display: grid;
  gap: 18px;
}

.blast-form {
  display: grid;
  grid-template-columns: minmax(0, 1fr) 300px;
  gap: 18px;
  align-items: stretch;
  padding: 18px 0;
}

.blast-input-panel,
.blast-options-panel {
  display: grid;
  gap: 14px;
  align-content: start;
  min-height: 304px;
  padding: 18px 20px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--panel);
}

.blast-input-panel {
  grid-template-rows: 1fr;
}

.blast-input-panel textarea {
  width: 100%;
  min-height: 224px;
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 12px 14px;
  background: #fff;
  color: var(--ink);
  font: 15px ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
  line-height: 1.55;
  resize: vertical;
}

.blast-result-card {
  display: grid;
  gap: 14px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--panel);
  overflow: hidden;
}

.blast-summary-grid {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: 10px;
  padding: 14px;
  background: #f6f8f7;
}

.blast-summary-grid article {
  display: grid;
  gap: 5px;
  min-height: 78px;
  padding: 13px 14px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fff;
}

.blast-summary-grid strong {
  color: var(--ink);
  font-size: 23px;
  line-height: 1.1;
}

.blast-summary-grid span {
  color: var(--muted);
  font-size: 13px;
}

.blast-hit-section {
  display: grid;
  gap: 10px;
  margin: 0 14px 14px;
  padding: 16px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fff;
}

.blast-hit-section h3 {
  margin: 0;
  color: var(--muted);
  font-size: 17px;
  text-transform: uppercase;
  letter-spacing: .08em;
}

.blast-table {
  min-width: 920px;
}

.blast-table th,
.blast-table td {
  padding: 10px 12px;
  vertical-align: middle;
  font-size: 15px;
}

.blast-table td > span {
  display: block;
  margin-top: 4px;
  color: var(--muted);
  font-size: 13px;
  line-height: 1.35;
}

.blast-locus-cell {
  min-width: 260px;
}

.blast-locus-cell strong {
  color: var(--ink);
  font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
  font-size: 14px;
}

.blast-gene-cell {
  min-width: 210px;
}

.blast-gene-cell .link-button {
  margin: 2px 6px 2px 0;
}

.blast-metric-cell {
  font-variant-numeric: tabular-nums;
  font-weight: 800;
  white-space: nowrap;
}

.blast-pager {
  display: flex;
  justify-content: flex-end;
  align-items: center;
  gap: 10px;
  color: var(--muted);
  font-size: 13px;
  font-weight: 800;
}

.blast-pager button {
  height: 30px;
  padding: 0 10px;
  font-size: 12px;
}

.blast-pager button:disabled {
  opacity: .45;
  cursor: not-allowed;
}

.empty-inline {
  color: var(--muted);
  font-size: 13px;
  font-weight: 750;
}

.primer-table {
  width: 100%;
  min-width: 0;
  table-layout: fixed;
}

.primer-table-wrap {
  overflow-x: visible;
}

.primer-table th,
.primer-table td {
  padding: 10px 8px;
  vertical-align: middle;
  font-size: 14px;
}

.primer-table th:nth-child(1),
.primer-table td:nth-child(1) {
  width: 44px;
}

.primer-table th:nth-child(2),
.primer-table td:nth-child(2) {
  width: 42%;
}

.primer-table th:nth-child(3),
.primer-table td:nth-child(3) {
  width: 18%;
}

.primer-table th:nth-child(4),
.primer-table td:nth-child(4) {
  width: 11%;
}

.primer-table th:nth-child(5),
.primer-table td:nth-child(5),
.primer-table th:nth-child(6),
.primer-table td:nth-child(6) {
  width: 8%;
}

.primer-table th:nth-child(7),
.primer-table td:nth-child(7) {
  width: 7%;
}

.primer-seq-cell {
  min-width: 0;
}

.primer-seq-cell div {
  display: grid;
  grid-template-columns: 66px minmax(0, 1fr) 28px;
  gap: 10px;
  align-items: center;
  margin: 4px 0;
}

.primer-seq-cell strong {
  color: var(--muted);
  font-size: 12px;
  text-transform: uppercase;
}

.primer-seq-cell code {
  color: var(--ink);
  font: 700 13.5px var(--sequence-font);
  white-space: nowrap;
  overflow: hidden;
  text-overflow: ellipsis;
  padding-left: 4px;
}

.primer-metric-cell {
  display: grid;
  gap: 4px;
  min-width: 0;
  color: var(--muted);
  font-size: 13px;
  white-space: nowrap;
}

.primer-track {
  position: relative;
  width: 100%;
  height: 50px;
  margin-bottom: 0;
}

.primer-track-line {
  position: absolute;
  left: 0;
  right: 0;
  top: 21px;
  height: 2px;
  background: #cbd8d2;
}

.primer-product,
.primer-forward,
.primer-reverse {
  position: absolute;
  border-radius: 3px;
}

.primer-product {
  top: 18px;
  height: 8px;
  background: #dce8e3;
}

.primer-forward {
  top: 13px;
  height: 12px;
  min-width: 7px;
  background: var(--accent);
}

.primer-reverse {
  top: 21px;
  height: 12px;
  min-width: 7px;
  background: #b14b36;
}

.primer-track-label {
  position: absolute;
  right: 0;
  bottom: 1px;
  color: var(--muted);
  font-size: 13px;
  font-weight: 800;
}

.primer-coord {
  display: block;
  color: var(--muted);
  font-size: 12px;
  font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
  white-space: nowrap;
  overflow: hidden;
  text-overflow: ellipsis;
}

.primer-table .gdna-copy {
  width: 26px;
  padding: 0;
  overflow: hidden;
  text-indent: -999px;
  position: relative;
}

.primer-table .gdna-copy::after {
  content: "C";
  position: absolute;
  inset: 0;
  display: grid;
  place-items: center;
  text-indent: 0;
  font-size: 11px;
}

.primer-table .guide-grade {
  min-height: 24px;
  padding: 0 7px;
  font-size: 12px;
}

.primer-advanced-note .placeholder-grid {
  margin-top: 0;
  grid-template-columns: repeat(2, minmax(0, 1fr));
}

.primer-amplicon-summary {
  display: grid;
  gap: 5px;
  min-width: 210px;
  color: var(--muted);
  font-size: 12px;
  line-height: 1.35;
}

.primer-amplicon-summary span:not(.guide-grade) {
  font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
}

.prioritizer-form {
  display: grid;
  grid-template-columns: minmax(0, 1fr) 300px;
  gap: 18px;
  align-items: stretch;
}

.prioritizer-input-panel,
.prioritizer-options-panel {
  display: grid;
  gap: 12px;
  align-content: start;
  min-height: 316px;
  padding: 16px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--panel);
}

.prioritizer-input-panel textarea {
  width: 100%;
  min-height: 214px;
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 12px 14px;
  background: #fff;
  color: var(--ink);
  font: 15px ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
  resize: vertical;
}

.prioritizer-input-panel .controls {
  margin-top: auto;
}

.prioritizer-options-panel input[type="number"] {
  width: 100%;
  height: 38px;
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 0 10px;
  background: #fff;
  color: var(--ink);
}

.genome-workflow {
  display: grid;
  gap: 18px;
}

.genome-view {
  width: calc(100vw - 88px);
  max-width: none;
  margin-left: calc(50% - 50vw + 44px);
  margin-right: calc(50% - 50vw + 44px);
}

.genome-view .module-head {
  max-width: 1180px;
}

.genome-browser {
  display: grid;
  gap: 0;
  padding: 6px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--panel);
}

.genome-status {
  min-height: 0;
  color: var(--muted);
  font-size: 14px;
}

.genome-region-summary {
  display: flex;
  flex-wrap: wrap;
  gap: 10px;
  align-items: baseline;
}

.genome-region-summary strong {
  color: var(--ink);
}

.genome-canvas {
  overflow-x: auto;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fff;
}

.jbrowse-frame {
  display: block;
  width: 100%;
  height: clamp(700px, 78vh, 760px);
  border: 0;
  background: #fff;
}

.genome-svg {
  display: block;
  width: 100%;
  min-width: 940px;
  height: auto;
}

.genome-bg {
  fill: #fff;
}

.genome-title {
  fill: var(--ink);
  font-size: 15px;
  font-weight: 800;
}

.genome-axis,
.genome-track-divider {
  stroke: #b8c6bf;
  stroke-width: 1.2;
}

.genome-tick,
.genome-track-label,
.genome-tx-label,
.genome-gene-label,
.genome-legend-text {
  fill: var(--muted);
  font-size: 12px;
}

.genome-track-label {
  font-weight: 800;
}

.genome-tx-label {
  font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
}

.genome-gene-label {
  fill: var(--ink);
  font-size: 11px;
}

.genome-gene {
  fill: #8fc1a9;
  stroke: #126b5b;
  stroke-width: .8;
}

.genome-gene.selected {
  fill: #d9a441;
  stroke: #8c6a16;
}

.genome-strand {
  fill: #126b5b;
}

.genome-intron {
  stroke: #a8b5ae;
  stroke-width: 1.2;
}

.genome-exon {
  fill: #b7d7c8;
  stroke: #6f9d87;
  stroke-width: .6;
}

.genome-cds {
  fill: var(--accent);
  stroke: #0d4f43;
  stroke-width: .7;
}

.functional-form {
  display: grid;
  grid-template-columns: minmax(0, 1fr) 280px;
  gap: 18px;
  align-items: stretch;
}

.functional-input-panel,
.functional-options-panel {
  display: grid;
  gap: 12px;
  align-content: start;
  padding: 16px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--panel);
}

.functional-input-panel {
  min-height: 316px;
}

.functional-options-panel {
  min-height: 316px;
}

.functional-input-panel textarea {
  width: 100%;
  min-height: 138px;
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 12px 14px;
  background: #fff;
  color: var(--ink);
  font: 15px ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
  resize: vertical;
}

.optional-label {
  color: var(--muted);
  font-weight: 600;
}

.functional-input-panel .controls {
  margin-top: auto;
}

.functional-options-panel select,
.functional-options-panel input[type="number"] {
  width: 100%;
  height: 38px;
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 0 10px;
  background: #fff;
  color: var(--ink);
}

.option-note {
  display: grid;
  gap: 5px;
  padding: 11px 12px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfcfb;
}

.option-note strong {
  color: var(--ink);
  font-size: 14px;
}

.option-note span {
  color: var(--muted);
  font-size: 13px;
  line-height: 1.45;
}

.confidence-box {
  display: grid;
  gap: 8px;
  color: var(--muted);
  font-size: 14px;
}

.confidence-box > span {
  color: var(--ink);
  font-weight: 800;
}

.confidence-box label {
  display: flex;
  align-items: center;
  gap: 8px;
}

.go-summary,
.go-category {
  display: grid;
  gap: 12px;
  margin-top: 16px;
  padding: 16px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--panel);
}

.go-category {
  padding: 0;
  overflow: hidden;
}

.go-category header {
  padding: 16px;
  border-bottom: 1px solid var(--line);
  background: #fbfcfb;
}

.go-summary header,
.go-category header {
  display: flex;
  align-items: start;
  justify-content: space-between;
  gap: 16px;
}

.go-overview-grid {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 10px;
}

.go-overview-grid article {
  display: grid;
  gap: 4px;
  padding: 9px 11px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfcfb;
}

.go-overview-grid strong {
  color: var(--accent);
  font-size: 19px;
  line-height: 1.1;
}

.go-overview-grid span {
  color: var(--muted);
  font-size: 12px;
}

.go-summary h2,
.go-category h3 {
  margin: 0;
  color: var(--ink);
}

.go-summary h2 {
  font-size: 22px;
}

.go-category h3 {
  font-size: 19px;
}

.go-summary header span,
.go-category header span {
  color: var(--muted);
  font-size: 13px;
  font-weight: 800;
  white-space: nowrap;
}

.go-section-toolbar {
  display: grid;
  grid-template-columns: 1fr;
  gap: 4px;
  margin: 10px 16px 12px;
}

.go-control-group {
  display: flex;
  flex-wrap: wrap;
  gap: 4px 7px;
  align-items: center;
  padding: 5px 8px;
  border: 1px solid #cfdcd6;
  border-left: 4px solid var(--accent);
  border-radius: 8px;
  background: #f3f8f5;
}

.go-display-group {
  background: #f3f8f5;
}

.go-filter-group {
  background: #f7faf8;
  border-left-color: #8fc1a9;
}

.go-chart-group,
.go-export-group {
  background: #fffaf0;
  border-left-color: #d9a441;
}

.go-chart-group {
  background: #f4faf7;
  border-left-color: #126b5b;
}

.go-control-group > strong {
  flex: 0 0 58px;
  color: var(--muted);
  font-size: 12px;
  font-weight: 800;
  text-transform: uppercase;
  letter-spacing: .04em;
}

.go-scope-tabs,
.go-level-tabs {
  display: flex;
  flex-wrap: wrap;
  gap: 4px;
  align-items: center;
}

.go-scope-tabs button,
.go-level-tabs button,
.go-control-group button {
  min-height: 22px;
  border: 1px solid var(--line);
  border-radius: 6px;
  padding: 0 7px;
  background: #fff;
  color: var(--muted);
  font-size: 11.5px;
  font-weight: 800;
  cursor: pointer;
}

.go-scope-tabs button.active,
.go-level-tabs button.active,
.go-control-group button.active {
  border-color: var(--accent);
  background: #e9f3ef;
  color: var(--accent);
}

.go-scope-tabs button {
  color: var(--ink);
}

.go-filter-group label {
  display: inline-flex;
  align-items: center;
  gap: 5px;
  color: var(--muted);
  font-size: 12px;
  font-weight: 800;
}

.go-filter-group input {
  width: 76px;
  height: 22px;
  border: 1px solid var(--line);
  border-radius: 6px;
  padding: 0 6px;
  background: #fff;
  color: var(--ink);
  font-size: 11.5px;
}

.go-row-check {
  width: 16px;
  height: 16px;
  accent-color: var(--accent);
}

.go-select-head {
  border: 0;
  background: transparent;
  color: var(--accent);
  font: inherit;
  font-weight: 800;
  cursor: pointer;
  padding: 0;
}

.go-select-head:hover {
  text-decoration: underline;
}

.go-chart-panel {
  overflow-x: auto;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fff;
  padding: 14px;
  margin: 0 16px 14px;
}

.go-chart-config {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
  align-items: center;
  margin: 0 16px 10px;
  padding: 9px 10px;
  border: 1px solid #cfdcd6;
  border-left: 4px solid #126b5b;
  border-radius: 8px;
  background: #f4faf7;
  color: var(--muted);
  font-size: 12px;
  font-weight: 800;
}

.go-chart-config-note {
  flex: 1 1 100%;
  color: var(--ink);
  font-size: 12px;
  font-weight: 750;
}

.go-chart-config label {
  display: inline-flex;
  align-items: center;
  gap: 5px;
}

.go-chart-config select,
.go-chart-config input {
  height: 24px;
  border: 1px solid var(--line);
  border-radius: 6px;
  padding: 0 22px 0 7px;
  background: #fff;
  color: var(--ink);
  font-size: 12px;
}

.go-chart-config input {
  width: 74px;
  padding: 0 7px;
}

.go-chart-config button {
  height: 24px;
  min-height: 24px;
  padding: 0 10px;
  font-size: 12px;
}

.go-chart-actions {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
  align-items: center;
  margin-bottom: 8px;
}

.go-chart-actions strong {
  color: var(--ink);
  font-size: 14px;
}

.go-chart-actions span {
  color: var(--muted);
  font-size: 13px;
  margin-right: auto;
}

.go-chart-actions button {
  min-height: 32px;
  border-radius: 6px;
  padding: 0 10px;
  font-size: 13px;
}

.go-bubble-chart {
  width: 100%;
  min-width: 0;
  max-width: 682px;
  height: auto;
  display: block;
  margin: 0 auto;
}

.go-bubble-square {
  max-width: 682px;
}

.go-bubble-rectangle {
  max-width: 642px;
}

.gofigure-panel {
  background: #fff;
}

.gofigure-svg-wrap {
  overflow-x: auto;
}

.gofigure-note {
  margin: 8px 0 0;
  color: var(--muted);
  font-size: 12px;
  line-height: 1.45;
}

.gofigure-svg {
  min-width: 0;
  max-width: 720px;
  width: min(100%, 720px);
  height: auto;
  display: block;
  margin: 0 auto;
}

.go-chart-frame {
  fill: #fff;
  stroke: #9ca8a2;
  stroke-width: 1;
}

.go-chart-grid {
  stroke: #c8d0cc;
  stroke-width: 1;
}

.go-chart-row-grid {
  stroke: #c8d0cc;
  stroke-dasharray: none;
}

.go-chart-term {
  fill: var(--ink);
  font-size: 14px;
  line-height: 1.2;
}

.go-chart-axis {
  fill: var(--muted);
  font-size: 12.5px;
}

.go-chart-label {
  fill: var(--ink);
  font-size: 13px;
  font-weight: 800;
}

.go-chart-bubble {
  stroke: rgba(20, 32, 27, .45);
  stroke-width: 1;
}

.go-chart-size {
  fill: #111;
  stroke: #111;
  stroke-width: 1;
}

.go-chart-gradient {
  stroke: #33423b;
  stroke-width: .8;
}

.go-table-wrap {
  max-height: 560px;
  margin: 0 16px 16px;
  border: 1px solid var(--line);
  border-radius: 8px;
}

.go-table {
  min-width: 980px;
  font-size: 13.5px;
}

.go-table th {
  white-space: nowrap;
}

.go-table td {
  padding: 5px 8px;
  line-height: 1.22;
  vertical-align: top;
}

.go-table td:nth-child(2) {
  min-width: 320px;
}

.go-table td:nth-child(2) strong {
  display: block;
  color: var(--accent);
  font-size: 12px;
}

.go-table td:nth-child(2) span {
  display: block;
  color: var(--ink);
  line-height: 1.25;
}

.prioritizer-summary,
.prioritizer-results-panel {
  display: grid;
  gap: 14px;
  margin-top: 18px;
  padding: 18px 20px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--panel);
}

.prioritizer-summary header,
.prioritizer-results-panel header {
  display: flex;
  align-items: flex-start;
  justify-content: space-between;
  gap: 16px;
}

.prioritizer-summary h2,
.prioritizer-results-panel h3 {
  margin: 0;
  color: var(--ink);
  font-size: 22px;
  line-height: 1.25;
}

.prioritizer-results-panel header p {
  margin: 4px 0 0;
  color: var(--muted);
  font-size: 14px;
  line-height: 1.45;
}

.prioritizer-table-wrap {
  border: 1px solid var(--line);
  border-radius: 8px;
}

.prioritizer-table {
  min-width: 1080px;
  font-size: 14px;
}

.prioritizer-table th,
.prioritizer-table td {
  padding: 10px 11px;
  line-height: 1.4;
}

.prioritizer-table th {
  color: var(--muted);
  font-size: 12px;
  font-weight: 900;
  letter-spacing: .02em;
  text-transform: uppercase;
}

.prioritizer-table td {
  vertical-align: top;
}

.prioritizer-table td:nth-child(4),
.prioritizer-table td:nth-child(n + 7) {
  color: var(--ink);
  font-weight: 850;
  text-align: right;
  white-space: nowrap;
}

.prioritizer-table td:nth-child(6) {
  max-width: 360px;
}

.prioritizer-table td:nth-child(6) strong {
  display: block;
  color: var(--accent);
  font-size: 14px;
  line-height: 1.25;
}

.prioritizer-table td:nth-child(6) span {
  display: block;
  margin-top: 4px;
  color: var(--muted);
  font-size: 13px;
  line-height: 1.4;
  white-space: normal;
}

.prioritizer-pager {
  display: flex;
  align-items: center;
  justify-content: flex-end;
  gap: 10px;
  color: var(--muted);
  font-size: 14px;
  font-weight: 800;
}

.prioritizer-pager button {
  height: 30px;
  padding: 0 10px;
  font-size: 12px;
}

.prioritizer-pager button:disabled {
  opacity: .45;
  cursor: not-allowed;
}

.score-bar {
  position: relative;
  display: inline-flex;
  align-items: center;
  width: 110px;
  height: 24px;
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: 999px;
  background: #eef4f1;
}

.score-bar i {
  position: absolute;
  inset: 0 auto 0 0;
  background: var(--accent);
}

.score-bar b {
  position: relative;
  z-index: 1;
  width: 100%;
  color: var(--ink);
  font-size: 12px;
  text-align: center;
}

.score-bar.wide {
  width: 100%;
  max-width: 360px;
  height: 28px;
}

.prioritizer-distribution-panel header p,
.prioritizer-results-panel header p {
  margin: 4px 0 0;
  color: var(--muted);
  font-size: 13px;
}

.prioritizer-total-distribution {
  display: grid;
  gap: 10px;
  padding: 8px 10px 4px;
}

.prioritizer-boxplot {
  position: relative;
  height: 34px;
}

.prioritizer-boxplot::before {
  content: "";
  position: absolute;
  left: 0;
  right: 0;
  top: 16px;
  height: 1px;
  background: #c8d2cc;
}

.prioritizer-box-whisker,
.prioritizer-box-iqr,
.prioritizer-box-median,
.prioritizer-box-observed {
  position: absolute;
  top: 50%;
  transform: translateY(-50%);
}

.prioritizer-box-whisker {
  height: 1px;
  background: #7c8983;
}

.prioritizer-box-iqr {
  height: 18px;
  border: 1px solid #6d7a74;
  background: #eef3f0;
}

.prioritizer-box-median {
  width: 2px;
  height: 22px;
  background: #151817;
}

.prioritizer-box-observed {
  width: 9px;
  height: 9px;
  border: 2px solid #151817;
  border-radius: 50%;
  background: #fff;
}

.prioritizer-score-points {
  position: relative;
  height: 18px;
}

.prioritizer-score-point {
  position: absolute;
  top: 2px;
  width: 10px;
  height: 10px;
  margin-left: -5px;
  border: 1px solid #151817;
  border-radius: 50%;
  padding: 0;
  background: var(--accent);
  cursor: pointer;
}

.prioritizer-score-point.anchor {
  border-color: #8a5b00;
  background: #d9a441;
}

.prioritizer-axis {
  display: flex;
  justify-content: space-between;
  color: var(--muted);
  font: 12px var(--sequence-font);
}

.prioritizer-subscore-boxgrid {
  display: grid;
  gap: 8px;
}

.prioritizer-subscore-boxrow {
  display: grid;
  grid-template-columns: 120px minmax(0, 1fr);
  gap: 12px;
  align-items: center;
}

.prioritizer-subscore-boxrow > span {
  color: var(--muted);
  font-size: 13px;
  font-weight: 800;
}

.subscore-cell {
  display: flex;
  flex-wrap: wrap;
  gap: 4px;
  max-width: 220px;
}

.subscore-cell span {
  display: inline-flex;
  align-items: center;
  min-height: 22px;
  border: 1px solid var(--line);
  border-radius: 999px;
  padding: 0 7px;
  background: #fbfcfb;
  color: var(--muted);
  font-size: 12px;
}

.prioritizer-anchor-panel {
  background: #fbfcfb;
}

.prioritizer-anchor-list {
  display: flex;
  flex-wrap: wrap;
  gap: 7px;
}

.prioritizer-anchor-list button {
  display: inline-grid;
  grid-template-columns: auto auto;
  gap: 6px;
  align-items: center;
  min-height: 28px;
  border: 1px solid var(--line);
  border-radius: 5px;
  padding: 4px 8px;
  background: #fff;
  color: var(--ink);
  cursor: pointer;
}

.prioritizer-anchor-list strong {
  font-size: 12px;
}

.prioritizer-anchor-list span,
.prioritizer-anchor-cell {
  color: var(--muted);
  font-size: 12px;
  white-space: nowrap;
}

.evidence-cell {
  max-width: 360px;
  white-space: normal;
}

.evidence-cell span {
  display: block;
  margin-bottom: 4px;
  color: var(--muted);
  line-height: 1.35;
}

.evidence-cell.large {
  max-width: none;
  padding: 12px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfcfb;
}

.prioritizer-detail-host {
  display: grid;
  gap: 14px;
}

.prioritizer-detail-panel {
  display: grid;
  gap: 16px;
  margin-top: 16px;
  padding: 18px 20px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fff;
}

.prioritizer-detail-panel header {
  display: flex;
  align-items: flex-start;
  justify-content: space-between;
  gap: 14px;
}

.prioritizer-detail-actions {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
  justify-content: flex-end;
}

.prioritizer-detail-panel h3,
.prioritizer-detail-panel h4 {
  margin: 0;
  color: var(--ink);
}

.prioritizer-detail-panel h3 {
  font-size: 22px;
  line-height: 1.25;
}

.prioritizer-detail-panel h4 {
  font-size: 16px;
  line-height: 1.25;
}

.prioritizer-detail-panel p {
  margin-top: 5px;
  color: var(--muted);
  font-size: 14px;
  line-height: 1.45;
}

.prioritizer-detail-grid {
  display: grid;
  grid-template-columns: minmax(0, 1.1fr) minmax(260px, .9fr);
  gap: 14px;
}

.prioritizer-subscore-plot,
.prioritizer-expression-plot,
.prioritizer-summary-panel,
.prioritizer-detail-explain {
  display: grid;
  gap: 12px;
  padding: 16px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fff;
}

.prioritizer-subscore-row {
  display: grid;
  grid-template-columns: 120px minmax(0, 1fr) 78px;
  gap: 10px;
  align-items: center;
}

.prioritizer-subscore-row > b {
  color: var(--ink);
  font-size: 12px;
  text-align: right;
}

.prioritizer-subscore-row > span,
.prioritizer-expression-row > span {
  color: var(--muted);
  font-size: 13px;
  font-weight: 800;
}

.prioritizer-expression-row {
  display: grid;
  grid-template-columns: 140px minmax(0, 1fr) 90px;
  gap: 10px;
  align-items: center;
}

.prioritizer-expression-row i {
  display: block;
  height: 16px;
  border-radius: 999px;
  background: var(--accent);
}

.prioritizer-expression-row b {
  color: var(--ink);
  font-size: 12px;
  text-align: right;
}

.prioritizer-summary-panel header {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 10px;
}

.prioritizer-class-badge {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  min-height: 32px;
  border: 1px solid var(--line);
  border-radius: 999px;
  padding: 0 12px;
  font-size: 13px;
  font-weight: 900;
  text-transform: uppercase;
}

.prioritizer-class-badge.high {
  border-color: #126b5b;
  background: #dceee7;
  color: #126b5b;
}

.prioritizer-class-badge.moderate {
  border-color: #d9a441;
  background: #fff6df;
  color: #8a6d1d;
}

.prioritizer-class-badge.low {
  border-color: #cfd6d2;
  background: #f3f5f4;
  color: var(--muted);
}

.prioritizer-summary-score {
  display: grid;
  gap: 4px;
  padding: 14px 16px;
  border: 1px solid var(--line);
  border-radius: 7px;
  background: #fbfcfb;
}

.prioritizer-summary-layout {
  display: grid;
  grid-template-columns: minmax(260px, .55fr) minmax(0, 1fr);
  gap: 16px;
}

.prioritizer-summary-score strong {
  color: var(--ink);
  font-size: 58px;
  line-height: 1;
}

.prioritizer-summary-score span {
  color: var(--muted);
  font-size: 15px;
  font-weight: 800;
}

.prioritizer-summary-kv {
  display: grid;
  grid-template-columns: 150px minmax(0, 1fr);
  gap: 8px 12px;
  align-content: center;
  padding: 14px 16px;
  border: 1px solid var(--line);
  border-radius: 7px;
  background: #fff;
}

.prioritizer-summary-kv span {
  color: var(--muted);
  font-size: 13px;
  font-weight: 850;
}

.prioritizer-summary-kv strong {
  color: var(--ink);
  font-size: 14px;
  line-height: 1.45;
}

.prioritizer-subscore-heatmap {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 8px 12px;
  padding-top: 12px;
  border-top: 1px solid var(--line);
}

.prioritizer-subscore-heatmap div {
  display: grid;
  grid-template-columns: 108px minmax(0, 1fr) 48px;
  gap: 10px;
  align-items: center;
}

.prioritizer-subscore-heatmap span {
  color: var(--muted);
  font-size: 13px;
  font-weight: 850;
}

.prioritizer-subscore-heatmap i {
  display: block;
  height: 22px;
  overflow: hidden;
  border: 1px solid #dfe5e2;
  border-radius: 4px;
  background: #f2f4f3;
}

.prioritizer-subscore-heatmap i b {
  display: block;
  height: 100%;
  border-radius: inherit;
  background: linear-gradient(90deg, #b7d7c8 0%, #126b5b 100%);
}

.prioritizer-subscore-heatmap strong {
  color: var(--ink);
  font-size: 13px;
  text-align: right;
}

.prioritizer-summary-evidence {
  display: flex;
  flex-wrap: wrap;
  gap: 6px;
  min-width: 0;
}

.prioritizer-summary-evidence span {
  display: inline-flex;
  align-items: center;
  min-height: 28px;
  border: 1px solid var(--line);
  border-radius: 5px;
  padding: 4px 8px;
  background: #fbfcfb;
  color: var(--muted);
  font-size: 13px;
  font-weight: 800;
  line-height: 1.25;
}

.prioritizer-kv {
  display: grid;
  grid-template-columns: 1fr auto;
  gap: 9px 14px;
  padding-top: 10px;
  border-top: 1px solid var(--line);
}

.prioritizer-kv span {
  color: var(--muted);
  font-size: 14px;
}

.prioritizer-kv strong {
  color: var(--ink);
  font-size: 14px;
}

.prioritizer-explain-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 10px;
}

.prioritizer-explain-grid article {
  display: grid;
  gap: 5px;
  padding: 11px 12px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfcfb;
}

.prioritizer-explain-grid strong {
  color: var(--ink);
  font-size: 13px;
}

.prioritizer-explain-grid span {
  color: var(--muted);
  font-size: 13px;
  line-height: 1.45;
}

.prioritizer-evidence-grid,
.prioritizer-metric-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 14px;
}

.prioritizer-heatmap-panel,
.prioritizer-metric-panel {
  display: grid;
  gap: 12px;
  padding: 16px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fff;
}

.prioritizer-heatmap-panel header,
.prioritizer-metric-panel header {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 12px;
  border-bottom: 1px solid var(--line);
  padding-bottom: 8px;
  min-height: 44px;
}

.prioritizer-heatmap-panel h4,
.prioritizer-metric-panel h4 {
  margin: 0;
  color: var(--ink);
}

.prioritizer-heatmap-panel header span,
.prioritizer-metric-panel header span {
  color: var(--muted);
  font-size: 13px;
  line-height: 1.4;
  text-align: right;
}

.prioritizer-heatmap-list {
  display: grid;
  gap: 8px;
}

.prioritizer-heatmap-row {
  display: grid;
  grid-template-columns: 132px minmax(0, 1fr) 36px;
  gap: 8px;
  align-items: start;
}

.prioritizer-heatmap-row strong {
  color: var(--ink);
  font-size: 12px;
  line-height: 1.35;
}

.prioritizer-heatmap-row em {
  color: var(--muted);
  font-size: 12px;
  font-style: normal;
  text-align: right;
}

.prioritizer-chip-grid {
  display: flex;
  flex-wrap: wrap;
  gap: 4px;
}

.prioritizer-go-chip-grid {
  align-content: start;
}

.prioritizer-chip {
  display: inline-flex;
  align-items: center;
  min-height: 22px;
  border: 1px solid var(--line);
  border-radius: 4px;
  padding: 2px 6px;
  background: #f7f8f7;
  color: #8a918d;
  font-size: 11.5px;
  line-height: 1.2;
}

.prioritizer-chip.hit {
  border-color: #9dc7b6;
  background: #e3f0eb;
  color: var(--accent);
  font-weight: 850;
}

.prioritizer-matrix {
  display: grid;
  gap: 10px;
}

.prioritizer-matrix-row {
  display: grid;
  grid-template-columns: 178px minmax(0, 1fr) 78px;
  gap: 10px;
  align-items: center;
  min-height: 35px;
}

.prioritizer-matrix-label {
  display: grid;
  gap: 2px;
}

.prioritizer-matrix-label strong {
  color: var(--ink);
  font-size: 13px;
  line-height: 1.3;
  overflow-wrap: anywhere;
}

.prioritizer-matrix-label span {
  color: var(--muted);
  font-size: 12px;
  font-weight: 800;
}

.prioritizer-matrix-cells {
  display: grid;
  gap: 3px;
  align-items: stretch;
}

.prioritizer-matrix-cell {
  display: block;
  position: relative;
  height: 24px;
  border: 1px solid #dfe5e2;
  border-radius: 3px;
  background: #f2f4f3;
}

.prioritizer-term-tip {
  cursor: help;
}

.prioritizer-term-tip::after {
  content: attr(data-term);
  position: absolute;
  left: 50%;
  bottom: calc(100% + 7px);
  z-index: 20;
  width: max-content;
  max-width: 240px;
  padding: 6px 8px;
  border: 1px solid #26302c;
  border-radius: 5px;
  background: #151817;
  color: #fff;
  font-size: 11.5px;
  font-weight: 800;
  line-height: 1.25;
  white-space: normal;
  opacity: 0;
  pointer-events: none;
  transform: translate(-50%, 3px);
  transition: opacity .08s ease, transform .08s ease;
}

.prioritizer-term-tip::before {
  content: "";
  position: absolute;
  left: 50%;
  bottom: calc(100% + 2px);
  z-index: 21;
  border: 5px solid transparent;
  border-top-color: #151817;
  opacity: 0;
  pointer-events: none;
  transform: translateX(-50%);
  transition: opacity .08s ease;
}

.prioritizer-term-tip:hover::after,
.prioritizer-term-tip:focus-visible::after,
.prioritizer-term-tip:hover::before,
.prioritizer-term-tip:focus-visible::before {
  opacity: 1;
  transform: translate(-50%, 0);
}

.prioritizer-term-tip:hover::before,
.prioritizer-term-tip:focus-visible::before {
  transform: translateX(-50%);
}

.prioritizer-matrix-cell.hit {
  border-color: #7fb59c;
  background: linear-gradient(180deg, #2b8069 0%, #126b5b 100%);
}

.prioritizer-matrix-score {
  display: grid;
  grid-template-columns: minmax(0, 1fr) auto;
  gap: 5px;
  align-items: center;
}

.prioritizer-matrix-score i {
  display: block;
  height: 10px;
  overflow: hidden;
  border-radius: 999px;
  background: #edf0ee;
}

.prioritizer-matrix-score b {
  display: block;
  height: 100%;
  border-radius: inherit;
  background: var(--accent);
}

.prioritizer-matrix-score em {
  color: var(--muted);
  font-size: 12px;
  font-style: normal;
  font-weight: 800;
  text-align: right;
}

.prioritizer-matrix-legend {
  display: flex;
  gap: 12px;
  align-items: center;
  padding-top: 2px;
  color: var(--muted);
  font-size: 12.5px;
  font-weight: 800;
}

.prioritizer-matrix-legend span {
  display: inline-flex;
  gap: 5px;
  align-items: center;
}

.prioritizer-matrix-legend i {
  display: inline-block;
  width: 13px;
  height: 13px;
  border: 1px solid #dfe5e2;
  border-radius: 3px;
  background: #f2f4f3;
}

.prioritizer-matrix-legend i.hit {
  border-color: #7fb59c;
  background: var(--accent);
}

.prioritizer-go-map {
  display: grid;
  gap: 10px;
}

.prioritizer-go-group {
  display: grid;
  grid-template-columns: 104px minmax(0, 1fr);
  gap: 9px;
  align-items: start;
}

.prioritizer-go-group > strong {
  color: var(--ink);
  font-size: 12px;
  line-height: 1.35;
}

.prioritizer-go-group > div {
  display: flex;
  flex-wrap: wrap;
  gap: 5px;
}

.prioritizer-go-node {
  display: inline-flex;
  align-items: center;
  min-height: 25px;
  border: 1px solid #dfe5e2;
  border-radius: 4px;
  padding: 3px 7px;
  background: #f3f5f4;
  color: #8a918d;
  font-size: 11.5px;
  line-height: 1.15;
}

.prioritizer-go-node.hit {
  border-color: #7fb59c;
  background: #dceee7;
  color: var(--accent);
  box-shadow: inset 0 -3px 0 rgba(18, 107, 91, .18);
  font-weight: 850;
}

.prioritizer-go-matrix {
  gap: 10px;
}

.prioritizer-go-row {
  grid-template-columns: 178px minmax(0, 1fr) 78px;
  min-height: 35px;
}

.prioritizer-go-cell {
  height: 24px;
}

.prioritizer-go-cell.hit {
  background: linear-gradient(180deg, #3f8d78 0%, #126b5b 100%);
}

.prioritizer-homology-sketch {
  position: relative;
  display: grid;
  gap: 9px;
  padding: 12px 13px 14px;
  border: 1px solid var(--line);
  border-radius: 7px;
  background: #fbfcfb;
}

.prioritizer-homology-ids {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 12px;
}

.prioritizer-homology-ids strong {
  color: var(--ink);
  font-size: 14px;
}

.prioritizer-homology-ids span {
  color: var(--accent);
  font-size: 14px;
  font-weight: 900;
  text-align: right;
}

.prioritizer-homology-track {
  display: grid;
  gap: 6px;
  padding: 2px 0;
}

.prioritizer-homology-track div {
  display: grid;
  grid-template-columns: minmax(0, 1fr) 72px;
  gap: 8px;
  align-items: center;
}

.prioritizer-homology-track div span {
  display: block;
  height: 13px;
  min-width: 2px;
  border-radius: 999px;
}

.prioritizer-homology-track div b {
  color: var(--muted);
  font-size: 12px;
  text-align: right;
  white-space: nowrap;
}

.prioritizer-homology-track div .smar {
  justify-self: start;
  background: #53645d;
}

.prioritizer-homology-track div .arabidopsis {
  justify-self: end;
  background: var(--accent);
}

.prioritizer-homology-track i {
  display: grid;
  grid-template-columns: minmax(0, 1fr) auto minmax(0, 1fr);
  gap: 7px;
  align-items: center;
}

.prioritizer-homology-track i::before,
.prioritizer-homology-track i::after {
  content: "";
  height: 1px;
  background: repeating-linear-gradient(90deg, #cbd5d0 0 6px, transparent 6px 10px);
}

.prioritizer-homology-track i b {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  min-height: 24px;
  border: 1px solid #b7d7c8;
  border-radius: 999px;
  padding: 0 8px;
  background: #edf5f2;
  color: var(--accent);
  font-size: 12px;
  font-style: normal;
  font-weight: 900;
  white-space: nowrap;
}

.prioritizer-expression-boxplots {
  display: grid;
  gap: 8px;
}

.prioritizer-expression-figure {
  display: grid;
  grid-template-columns: minmax(170px, .9fr) minmax(0, 1.1fr);
  gap: 14px;
  align-items: stretch;
  height: 100%;
}

.prioritizer-cpm-plot {
  display: grid;
  grid-template-columns: 34px minmax(0, 1fr);
  grid-template-rows: minmax(170px, 1fr) auto;
  gap: 7px 10px;
  min-height: 220px;
  padding: 10px 8px 8px 0;
  border: 1px solid var(--line);
  border-radius: 7px;
  background: #fbfcfb;
}

.prioritizer-cpm-axis {
  display: grid;
  grid-template-rows: auto minmax(0, 1fr) auto;
  color: var(--muted);
  font-size: 11.5px;
  font-weight: 800;
  text-align: right;
}

.prioritizer-cpm-axis i {
  justify-self: end;
  width: 1px;
  background: repeating-linear-gradient(180deg, #c4cec9 0 5px, transparent 5px 9px);
}

.prioritizer-cpm-boxes {
  display: grid;
  grid-template-columns: repeat(2, minmax(54px, 1fr));
  gap: 16px;
  align-items: stretch;
}

.prioritizer-cpm-boxgroup {
  display: grid;
  grid-template-rows: minmax(140px, 1fr) auto auto;
  gap: 5px;
  justify-items: center;
  min-width: 0;
}

.prioritizer-cpm-vbox {
  position: relative;
  width: 52px;
  height: 100%;
  min-height: 168px;
  background:
    linear-gradient(180deg, transparent calc(25% - .5px), #edf0ee calc(25% - .5px), #edf0ee calc(25% + .5px), transparent calc(25% + .5px)),
    linear-gradient(180deg, transparent calc(50% - .5px), #edf0ee calc(50% - .5px), #edf0ee calc(50% + .5px), transparent calc(50% + .5px)),
    linear-gradient(180deg, transparent calc(75% - .5px), #edf0ee calc(75% - .5px), #edf0ee calc(75% + .5px), transparent calc(75% + .5px));
}

.prioritizer-cpm-vbox .whisker {
  position: absolute;
  left: 50%;
  width: 1px;
  background: #151817;
  transform: translateX(-50%);
}

.prioritizer-cpm-vbox .iqr {
  position: absolute;
  left: 50%;
  width: 30px;
  border: 1.5px solid #151817;
  border-radius: 2px;
  background: #fff;
  transform: translateX(-50%);
}

.prioritizer-cpm-vbox .median {
  position: absolute;
  left: 50%;
  width: 30px;
  height: 1.5px;
  background: #151817;
  transform: translate(-50%, 1px);
}

.prioritizer-cpm-vbox .cap {
  position: absolute;
  left: 50%;
  width: 20px;
  height: 1.5px;
  background: #151817;
  transform: translateX(-50%);
}

.prioritizer-cpm-vbox .observed {
  position: absolute;
  left: 50%;
  width: 10px;
  height: 10px;
  border: 1.5px solid #151817;
  border-radius: 999px;
  background: var(--accent);
  transform: translate(-50%, 50%);
}

.prioritizer-cpm-boxgroup strong {
  color: var(--ink);
  font-size: 13px;
}

.prioritizer-cpm-boxgroup em {
  color: var(--muted);
  font-size: 12px;
  font-style: normal;
  font-weight: 800;
}

.prioritizer-cpm-plot p {
  grid-column: 1 / 3;
  margin: 0;
  color: var(--muted);
  font-size: 12px;
  font-weight: 850;
  text-align: center;
}

.prioritizer-expression-summary {
  display: grid;
  gap: 10px;
  align-content: stretch;
  min-width: 0;
  padding: 12px 14px;
  border: 1px solid var(--line);
  border-radius: 7px;
  background: #fff;
}

.prioritizer-expression-boxrow {
  display: grid;
  grid-template-columns: 132px minmax(0, 1fr) 78px;
  gap: 9px;
  align-items: center;
}

.prioritizer-expression-boxrow > span {
  color: var(--muted);
  font-size: 12.5px;
  font-weight: 800;
  line-height: 1.25;
}

.prioritizer-expression-boxrow > b {
  color: var(--ink);
  font-size: 12px;
  text-align: right;
}

.prioritizer-expression-axis {
  display: grid;
  grid-template-columns: 132px minmax(0, 1fr) 78px;
  gap: 9px;
  color: var(--muted);
  font-size: 10.5px;
  font-weight: 800;
}

.prioritizer-expression-axis span:nth-child(2) {
  text-align: center;
}

.prioritizer-expression-axis span:nth-child(3) {
  text-align: right;
}

.prioritizer-tau-gauge {
  display: grid;
  gap: 5px;
  padding-top: 8px;
  border-top: 1px solid var(--line);
}

.prioritizer-tau-track {
  position: relative;
  height: 11px;
  border-radius: 999px;
  background: linear-gradient(90deg, #dfe5e2 0%, #b7d7c8 50%, #126b5b 100%);
}

.prioritizer-tau-track span {
  position: absolute;
  top: 50%;
  width: 13px;
  height: 13px;
  border: 2px solid #151817;
  border-radius: 999px;
  background: #fff;
  transform: translate(-50%, -50%);
}

.prioritizer-tau-axis {
  display: flex;
  justify-content: space-between;
  color: var(--muted);
  font-size: 12px;
}

.prioritizer-tau-gauge > strong {
  color: var(--ink);
  font-size: 13.5px;
  text-align: right;
}

.prioritizer-model-figure,
.prioritizer-neighborhood-figure {
  display: grid;
  gap: 10px;
  padding: 12px 13px;
  border: 1px solid var(--line);
  border-radius: 7px;
  background: #fbfcfb;
}

.prioritizer-model-track,
.prioritizer-neighborhood-track {
  position: relative;
  height: 66px;
}

.prioritizer-model-track > i,
.prioritizer-neighborhood-track > i {
  position: absolute;
  left: 0;
  right: 0;
  top: 50%;
  height: 2px;
  background: #cbd5d0;
  transform: translateY(-50%);
}

.prioritizer-model-track span {
  position: absolute;
  top: 50%;
  min-width: 2px;
  border-radius: 2px;
  transform: translateY(-50%);
}

.prioritizer-model-track span.exon {
  height: 20px;
  border: 1px solid #9a6b00;
  background: #e2aa2f;
  z-index: 2;
}

.prioritizer-model-track span.cds {
  height: 11px;
  background: #183f38;
  z-index: 3;
}

.prioritizer-model-track .dir-arrow {
  position: absolute;
  top: 50%;
  width: 0;
  height: 0;
  border-top: 5px solid transparent;
  border-bottom: 5px solid transparent;
  border-left: 8px solid #7a817d;
  transform: translate(-50%, -50%);
  z-index: 1;
}

.prioritizer-model-track .dir-arrow.reverse {
  border-left: 0;
  border-right: 8px solid #7a817d;
}

.prioritizer-model-axis,
.prioritizer-neighborhood-axis {
  display: flex;
  justify-content: space-between;
  gap: 10px;
  color: var(--muted);
  font-size: 12px;
  font-weight: 800;
}

.prioritizer-model-axis strong,
.prioritizer-neighborhood-axis strong {
  color: var(--ink);
  font-weight: 900;
  text-align: center;
}

.prioritizer-model-legend {
  display: flex;
  gap: 12px;
  color: var(--muted);
  font-size: 12.5px;
  font-weight: 850;
}

.prioritizer-model-legend span {
  display: inline-flex;
  gap: 5px;
  align-items: center;
}

.prioritizer-model-legend i {
  display: inline-block;
  width: 16px;
  height: 8px;
  border-radius: 2px;
}

.prioritizer-model-legend i.exon {
  background: #e2aa2f;
}

.prioritizer-model-legend i.cds {
  background: #183f38;
}

.prioritizer-neighborhood-track button {
  position: absolute;
  top: 50%;
  min-width: 4px;
  border: 0;
  border-radius: 3px;
  padding: 0;
  transform: translateY(-50%);
}

.prioritizer-neighborhood-track .focus {
  height: 22px;
  background: var(--accent);
  z-index: 2;
}

.prioritizer-neighborhood-track .neighbor {
  height: 15px;
  background: #d9a441;
  cursor: help;
}

.prioritizer-neighbor-list {
  display: flex;
  flex-wrap: wrap;
  gap: 5px;
}

.prioritizer-neighbor-list span,
.prioritizer-neighbor-list button {
  display: inline-flex;
  gap: 5px;
  align-items: center;
  min-height: 26px;
  border: 1px solid var(--line);
  border-radius: 5px;
  padding: 3px 7px;
  background: #fff;
  color: var(--ink);
  font-size: 12.5px;
  font-weight: 850;
  cursor: pointer;
}

.prioritizer-neighbor-list span {
  cursor: default;
}

.prioritizer-neighbor-list button:hover {
  border-color: var(--accent);
  background: #edf5f2;
  color: var(--accent);
}

.prioritizer-neighbor-list b {
  color: var(--muted);
  font-size: 12px;
}

.prioritizer-table .prioritizerDetailBtn {
  height: 28px;
  margin-left: 0;
  padding: 0 10px;
  border-color: #b7d7c8;
  background: #edf5f2;
  color: var(--accent);
  font-size: 12px;
  font-weight: 900;
}

.prioritizer-metric-panel {
  align-content: start;
}

.prioritizer-metric-row {
  display: grid;
  grid-template-columns: 152px minmax(0, 1fr) 92px;
  gap: 10px;
  align-items: center;
}

.prioritizer-metric-row span {
  color: var(--muted);
  font-size: 13.5px;
  font-weight: 800;
}

.prioritizer-metric-row i {
  display: block;
  height: 14px;
  overflow: hidden;
  border: 1px solid #d9e0dd;
  border-radius: 999px;
  background: #f4f6f5;
}

.prioritizer-metric-row i b {
  display: block;
  height: 100%;
  border-radius: inherit;
  background: var(--accent);
}

.prioritizer-metric-row strong {
  color: var(--ink);
  font-size: 13.5px;
  text-align: right;
}

.prioritizer-kv.compact {
  gap: 6px 10px;
  padding-top: 6px;
}

.prioritizer-kv.compact span,
.prioritizer-kv.compact strong {
  font-size: 13.5px;
}

button.mini {
  height: 26px;
  margin-left: 6px;
  padding: 0 8px;
  font-size: 12px;
}

.placeholder-panel {
  display: grid;
  gap: 14px;
  margin-top: 24px;
  padding: 22px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--panel);
}

.placeholder-panel h2 {
  margin: 0;
  color: var(--ink);
  font-size: 24px;
}

.placeholder-panel p {
  margin: 0;
  color: var(--muted);
  line-height: 1.65;
}

.block h3,
.blast-hit-section h3,
.guide-result-section h3,
.primer-result-card h3,
.blast-result-card h3,
.go-category h3,
.candidate-rank-section h4,
.pair-domain-section h4,
.tree-title,
.prioritizer-results-panel h3,
.prioritizer-detail-panel h4,
.prioritizer-heatmap-panel h4,
.prioritizer-metric-panel h4 {
  color: var(--muted);
  font-size: 13px;
  font-weight: 900;
  letter-spacing: .08em;
  line-height: 1.25;
  text-transform: uppercase;
}

.multi-head h2,
.go-summary h2,
.primer-result-card .multi-head h2,
.blast-result-card .multi-head h2 {
  color: var(--ink);
  font-size: 22px;
  font-weight: 850;
  letter-spacing: 0;
  line-height: 1.25;
  text-transform: none;
}

.block p,
.go-summary header span,
.go-category header span,
.prioritizer-results-panel header p,
.prioritizer-detail-panel p,
.guide-method-note p,
.placeholder-panel p {
  color: var(--muted);
  font-size: 14px;
  line-height: 1.55;
}

.block h3 + *,
.guide-result-section h3 + *,
.blast-hit-section h3 + *,
.primer-result-card h3 + *,
.prioritizer-detail-panel h4 + *,
.prioritizer-heatmap-panel h4 + *,
.prioritizer-metric-panel h4 + * {
  margin-top: 2px;
}

.placeholder-grid {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 12px;
  margin-top: 4px;
}

.placeholder-grid article {
  display: grid;
  gap: 6px;
  padding: 14px 16px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfcfb;
}

.placeholder-grid strong {
  color: var(--ink);
  font-size: 14px;
}

.placeholder-grid span {
  color: var(--muted);
  font-size: 14px;
  line-height: 1.45;
}

.guide-form {
  padding: 18px 0;
}

.guide-method-note {
  display: grid;
  gap: 6px;
  padding: 16px 18px;
  border: 1px solid var(--line);
  border-left: 4px solid var(--accent);
  border-radius: 8px;
  background: #fbfcfb;
}

.guide-method-note strong {
  color: var(--ink);
  font-size: 15px;
}

.guide-method-note p {
  margin: 0;
  color: var(--muted);
  font-size: 15px;
  line-height: 1.6;
}

.guide-method-note ol {
  margin: 0;
  padding-left: 20px;
  color: var(--muted);
  font-size: 15px;
  line-height: 1.55;
}

.guide-method-note li + li {
  margin-top: 5px;
}

.atProteinChoice {
  width: 16px;
  height: 16px;
  accent-color: var(--accent);
}

.guide-grid {
  display: grid;
  grid-template-columns: minmax(0, 1fr) 320px;
  gap: 18px;
  align-items: stretch;
}

.guide-input-panel,
.guide-options-panel,
.guide-result-card {
  padding: 18px 20px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--panel);
}

.guide-summary-grid {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: 10px;
  margin: 14px 0;
}

.guide-summary-grid article {
  display: grid;
  gap: 5px;
  min-height: 82px;
  padding: 13px 14px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfcfb;
}

.guide-summary-grid strong {
  color: var(--ink);
  font-size: 24px;
  line-height: 1.1;
}

.guide-summary-grid span {
  color: var(--muted);
  font-size: 13px;
  line-height: 1.35;
}

.guide-summary-grid .guide-best {
  border-left: 5px solid var(--accent);
}

.guide-summary-grid .guide-best strong {
  color: var(--accent);
  font: 16px ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
  word-break: break-all;
}

.guide-result-section {
  display: grid;
  gap: 10px;
  margin-top: 14px;
  padding: 16px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfcfb;
}

.guide-result-section.emphasized {
  border-left: 1px solid var(--line);
  background: #f7f8f7;
}

.guide-result-section h3 {
  margin: 0;
  color: var(--ink);
  font-size: 17px;
  text-transform: uppercase;
  letter-spacing: .08em;
}

.guide-input-panel,
.guide-options-panel {
  display: grid;
  gap: 14px;
  align-content: start;
  min-height: 314px;
}

.guide-input-panel {
  grid-template-rows: auto auto 1fr;
}

.guide-sequence-wrap textarea {
  min-height: 176px;
}

.segmented {
  display: inline-flex;
  flex-wrap: wrap;
  gap: 6px;
  padding: 4px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfcfb;
}

.segmented label {
  display: inline-flex;
  align-items: center;
  gap: 7px;
  min-height: 34px;
  padding: 0 10px;
  border-radius: 6px;
  color: var(--muted);
  font-size: 14px;
  font-weight: 700;
  cursor: pointer;
}

.segmented label:has(input:checked) {
  background: var(--accent);
  color: #fff;
}

.segmented input {
  accent-color: var(--accent);
}

.field-label {
  display: grid;
  gap: 7px;
  color: var(--muted);
  font-size: 14px;
  font-weight: 750;
}

.field-label input {
  width: 100%;
  height: 42px;
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 0 12px;
  background: var(--panel);
  color: var(--ink);
  font: 16px ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
}

.field-label input:disabled {
  background: #f0f2f1;
  color: var(--muted);
}

.guide-actions {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
  margin-top: auto;
}

.guide-table code {
  font: 13px var(--sequence-font);
  white-space: nowrap;
}

.guide-protospacer {
  color: var(--ink);
}

.guide-pam {
  margin-left: 2px;
  color: #b14b36;
  font-weight: 850;
}

.guide-sort {
  appearance: none;
  border: 0;
  padding: 0;
  background: transparent;
  color: inherit;
  font: inherit;
  font-weight: 800;
  cursor: pointer;
  white-space: nowrap;
}

.guide-sort:hover {
  color: var(--ink);
}

.guide-sort span {
  color: #5f6b66;
  font-size: 11px;
}

.gdna-btn {
  height: 24px;
  border: 1px solid var(--line);
  border-radius: 5px;
  padding: 0 7px;
  background: #fbfcfb;
  color: var(--ink);
  font-size: 12px;
  font-weight: 800;
  cursor: pointer;
}

.gdna-btn:hover {
  border-color: #9aa7a1;
  background: #f0f2f1;
}

.guide-table th,
.guide-table td {
  padding: 8px 9px;
  vertical-align: middle;
}

.guide-table {
  background: #fff;
}

.guide-table th {
  white-space: nowrap;
  background: #eef1ef;
  color: var(--ink);
}

.guide-table tbody tr:nth-child(even) {
  background: #fafbfa;
}

.guide-table tbody tr:hover {
  background: #f0f2f1;
}

.guide-table .num-cell {
  text-align: right;
  font-variant-numeric: tabular-nums;
  white-space: nowrap;
}

.guide-caution-cell {
  min-width: 180px;
  max-width: 280px;
  color: var(--muted);
  font-size: 13px;
  line-height: 1.35;
}

.gdna-panel {
  display: grid;
  gap: 14px;
  margin-top: 16px;
  padding: 18px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfcfb;
}

.gdna-head {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 12px;
}

.gdna-head div {
  display: grid;
  gap: 3px;
}

.gdna-head strong {
  color: var(--ink);
  font-size: 18px;
}

.gdna-head span {
  color: var(--muted);
  font-size: 14px;
  font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
}

.gdna-track {
  position: relative;
  height: 144px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--panel);
  overflow: hidden;
}

.gdna-gene-label {
  position: absolute;
  left: 18px;
  top: 10px;
  max-width: calc(100% - 170px);
  color: var(--muted);
  font-size: 13px;
  font-weight: 800;
  overflow: hidden;
  text-overflow: ellipsis;
  white-space: nowrap;
}

.gdna-line {
  position: absolute;
  top: 78px;
  height: 2px;
  background: #bfc9c4;
}

.gdna-guide,
.gdna-pam-bar {
  position: absolute;
  top: 40px;
  min-width: 4px;
  height: 13px;
  border-radius: 3px;
}

.gdna-guide {
  background: #53645d;
}

.gdna-ref-arrow {
  position: absolute;
  top: 74px;
  width: 12px;
  height: 10px;
  color: #7a817d;
}

.gdna-ref-arrow::after {
  content: "";
  position: absolute;
  top: 1px;
  left: 2px;
  width: 0;
  height: 0;
  border-top: 4px solid transparent;
  border-bottom: 4px solid transparent;
  border-left: 7px solid currentColor;
}

.gdna-ref-arrow.reverse::after {
  border-left: 0;
  border-right: 7px solid currentColor;
}

.gdna-target-arrow {
  position: absolute;
  top: 40px;
  width: 18px;
  height: 13px;
  color: #53645d;
}

.gdna-target-arrow::before {
  content: "";
  position: absolute;
  left: 0;
  right: 5px;
  top: 6px;
  height: 2px;
  background: currentColor;
}

.gdna-target-arrow::after {
  content: "";
  position: absolute;
  right: 0;
  top: 2px;
  width: 0;
  height: 0;
  border-top: 5px solid transparent;
  border-bottom: 5px solid transparent;
  border-left: 7px solid currentColor;
}

.gdna-target-arrow.reverse {
  transform: translateX(-100%);
}

.gdna-target-arrow.reverse::before {
  left: 5px;
  right: 0;
}

.gdna-target-arrow.reverse::after {
  left: 0;
  right: auto;
  border-left: 0;
  border-right: 7px solid currentColor;
}

.gdna-pam-bar {
  top: 40px;
  background: #b14b36;
}

.gdna-exon {
  position: absolute;
  top: 72px;
  min-width: 5px;
  height: 12px;
  border-radius: 3px;
  background: #d9a441;
}

.gdna-legend {
  position: absolute;
  left: 18px;
  right: 18px;
  bottom: 14px;
  display: flex;
  flex-wrap: wrap;
  gap: 12px;
  color: var(--muted);
  font-size: 13px;
  font-weight: 800;
}

.gdna-legend span {
  display: inline-flex;
  align-items: center;
  gap: 5px;
}

.gdna-legend i {
  display: inline-block;
  width: 14px;
  height: 8px;
  border-radius: 2px;
}

.legend-guide {
  background: #53645d;
}

.legend-pam {
  background: #b14b36;
}

.legend-exon {
  background: #d9a441;
}

.gdna-sequence-blocks {
  display: grid;
  gap: 12px;
}

.gdna-seq-card {
  display: grid;
  gap: 8px;
  padding: 12px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--panel);
}

.gdna-seq-head {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 10px;
}

.gdna-sequence-blocks dt {
  color: var(--muted);
  font-size: 13px;
  font-weight: 800;
  text-transform: uppercase;
}

.gdna-sequence-blocks dd {
  margin: 0;
  color: var(--ink);
  font-size: 15px;
}

.gdna-sequence-blocks code {
  font: 14px var(--sequence-font);
  line-height: 1.55;
  word-break: break-all;
}

.gdna-copy {
  height: 26px;
  border: 1px solid var(--line);
  border-radius: 5px;
  padding: 0 9px;
  background: #fbfcfb;
  color: var(--accent);
  font-size: 12px;
  font-weight: 800;
  cursor: pointer;
}

.gdna-copy:hover {
  border-color: var(--accent);
  background: #edf5f2;
}

.gdna-toggle {
  display: inline-flex;
  align-items: center;
  gap: 7px;
  color: var(--muted);
  font-size: 14px;
  font-weight: 800;
}

.gdna-toggle input {
  accent-color: var(--accent);
}

.guide-pager {
  display: flex;
  align-items: center;
  justify-content: flex-end;
  gap: 10px;
  margin-top: 14px;
  color: var(--muted);
  font-size: 14px;
  font-weight: 700;
}

.guide-pager button:disabled {
  opacity: 0.45;
  cursor: not-allowed;
}

.score-pill {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  min-width: 40px;
  height: 28px;
  border-radius: 999px;
  background: #edf5f2;
  color: var(--accent);
  font-weight: 800;
}

.caution-tag {
  margin: 2px 3px 2px 0;
  background: #fffaf0;
  border-color: #d9a441;
}

.guide-grade {
  display: inline-flex;
  align-items: center;
  min-height: 28px;
  border: 1px solid var(--line);
  border-radius: 999px;
  padding: 0 10px;
  font-size: 13px;
  font-weight: 800;
  white-space: nowrap;
}

.grade-good {
  border-color: #126b5b;
  background: #edf5f2;
  color: #126b5b;
}

.grade-ok {
  border-color: #8fc1a9;
  background: #f4faf7;
  color: #315f51;
}

.grade-warn {
  border-color: #d9a441;
  background: #fffaf0;
  color: #8a6d1d;
}

.grade-bad {
  border-color: #b14b36;
  background: #fff3ef;
  color: #b14b36;
}

.grade-neutral {
  background: #f0f2f1;
  color: var(--muted);
}

.confirm-panel {
  display: grid;
  gap: 12px;
}

.confirm-card {
  padding: 18px 20px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--panel);
}

.confirm-card h3 {
  margin: 0 0 12px;
  font-size: 19px;
  text-transform: uppercase;
  letter-spacing: .08em;
  color: var(--muted);
}

.protein-choice {
  display: flex;
  gap: 10px;
  align-items: center;
  margin-top: 14px;
  color: var(--muted);
  font-size: 15px;
}

.confirm-actions {
  margin-top: 14px;
}

.candidate-group {
  padding: 0;
  margin: 16px 20px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fff;
  overflow: hidden;
}

.candidate-group h3 {
  margin: 18px 20px 12px;
  font-size: 19px;
  text-transform: uppercase;
  letter-spacing: .08em;
  color: var(--muted);
}

.query-summary {
  display: flex;
  align-items: center;
  gap: 10px;
  flex-wrap: wrap;
  padding: 18px 20px;
  cursor: pointer;
  list-style: none;
  background: #fbfcfb;
  border-bottom: 1px solid var(--line);
}

.query-summary::-webkit-details-marker {
  display: none;
}

.query-summary::before {
  content: "›";
  display: inline-grid;
  place-items: center;
  width: 22px;
  height: 22px;
  border: 1px solid var(--line);
  border-radius: 999px;
  color: var(--accent);
  font-size: 18px;
  transform: rotate(0deg);
}

.candidate-group[open] .query-summary::before {
  transform: rotate(90deg);
}

.query-title {
  font-size: 25px;
  font-weight: 780;
  color: var(--ink);
}

.query-pill {
  display: inline-flex;
  align-items: center;
  min-height: 28px;
  border: 1px solid var(--line);
  border-radius: 999px;
  padding: 0 11px;
  color: var(--muted);
  font-size: 13px;
}

.pair-domain-section {
  margin: 18px 20px 20px;
  display: grid;
  gap: 12px;
}

.pairwise-detail-panel {
  margin-top: 0;
}

.pair-domain-section.emphasized {
  padding: 16px;
  border: 1px solid #b7d7c8;
  border-left: 5px solid var(--accent);
  border-radius: 8px;
  background: #f4faf7;
}

.pair-domain-section h4 {
  margin: 0;
  font-size: 18px;
  text-transform: uppercase;
  letter-spacing: .08em;
  color: var(--muted);
}

.pairwise-focus-head {
  display: flex;
  align-items: flex-start;
  justify-content: space-between;
  gap: 12px;
}

.pairwise-focus-head div {
  display: grid;
  gap: 4px;
}

.pairwise-focus-head strong {
  color: var(--ink);
  font-size: 16px;
}

.pairwise-focus-head span {
  color: var(--muted);
  font-size: 13px;
}

.pairwise-selected {
  display: flex;
  flex-wrap: wrap;
  gap: 10px;
  align-items: baseline;
  padding: 10px 12px;
  border-radius: 6px;
  background: #edf5f2;
}

.pairwise-selected strong {
  color: var(--accent);
  font-size: 16px;
}

.pairwise-selected span {
  color: var(--muted);
  font-size: 13px;
}

.pair-domain-map {
  width: 100%;
  max-width: 980px;
  min-height: 150px;
  border: 1px solid var(--line);
  border-radius: 6px;
  background: #fbfcfb;
}

.domain-matrix-wrap {
  overflow-x: auto;
}

.domain-matrix {
  min-width: 620px;
  background: #fff;
}

.domain-matrix th,
.domain-matrix td {
  text-align: center;
}

.domain-matrix th:first-child,
.domain-matrix td:first-child {
  text-align: left;
}

.domain-matrix-row {
  cursor: pointer;
}

.domain-matrix-row.active {
  background: #e4f1eb;
  outline: 2px solid rgba(18, 107, 91, .22);
  outline-offset: -2px;
}

.identity-cell {
  width: 82px;
  height: 32px;
  border-radius: 6px;
  padding: 0 8px;
  color: var(--ink);
  font-size: 14px;
  font-weight: 700;
}

.identity-high {
  background: #2d7a62;
  color: #fff;
}

.identity-mid {
  background: #8fc1a9;
}

.identity-low {
  background: #d3e7dc;
}

.identity-weak {
  background: #eef4f1;
}

.identity-none {
  background: #f0f2f1;
  color: var(--muted);
}

.domain-detail {
  display: grid;
  gap: 12px;
  padding: 12px;
  border: 1px solid var(--line);
  border-radius: 6px;
  background: #fff;
}

.candidate-rank-section {
  display: grid;
  gap: 10px;
  margin: 18px 20px 20px;
}

.candidate-rank-section h4 {
  margin: 0;
  color: var(--muted);
  font-size: 15px;
  text-transform: uppercase;
  letter-spacing: .08em;
}

.candidate-expression-section {
  display: grid;
  gap: 12px;
  margin: 0 20px 20px;
  padding: 16px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fff;
  overflow-x: auto;
}

.candidate-expression-section header {
  display: flex;
  align-items: flex-start;
  justify-content: space-between;
  gap: 12px;
}

.candidate-expression-section h4 {
  margin: 0;
  color: var(--muted);
  font-size: 15px;
  font-weight: 900;
  letter-spacing: .08em;
  line-height: 1.25;
  text-transform: uppercase;
}

.candidate-expression-section p {
  margin: 4px 0 0;
  color: var(--muted);
  font-size: 13px;
  line-height: 1.35;
}

.candidate-expression-grid {
  display: grid;
  grid-template-columns: minmax(140px, .9fr) repeat(var(--heatmap-cols), minmax(62px, 78px));
  gap: 3px;
  align-items: stretch;
  justify-self: center;
  min-width: 680px;
}

.candidate-expression-corner,
.candidate-expression-sample {
  min-height: 26px;
}

.candidate-expression-sample {
  display: flex;
  align-items: center;
  justify-content: center;
  color: var(--muted);
  font-size: 12px;
  font-weight: 850;
}

.candidate-expression-gene {
  min-width: 0;
  height: 30px;
  border: 0;
  border-radius: 0;
  padding: 0 8px 0 0;
  background: transparent;
  color: var(--accent);
  font-family: var(--sequence-font);
  font-size: 13.5px;
  font-weight: 850;
  text-align: right;
  text-decoration: underline;
  text-underline-offset: 3px;
}

.candidate-expression-cell {
  display: flex;
  align-items: center;
  justify-content: center;
  min-height: 30px;
  border: 1px solid rgba(100, 112, 107, .2);
  border-radius: 1px;
  color: #151817;
  font-family: var(--sequence-font);
  font-size: 11.5px;
  font-weight: 500;
  line-height: 1;
}

.candidate-expression-legend {
  display: grid;
  grid-template-columns: auto minmax(120px, 220px) auto;
  gap: 8px;
  align-items: center;
  justify-content: end;
  color: var(--muted);
  font-size: 12px;
  font-weight: 750;
}

.candidate-expression-legend i {
  display: block;
  height: 10px;
  border: 1px solid rgba(100, 112, 107, .22);
  border-radius: 999px;
  background: linear-gradient(90deg, #f6f8f7, #126b5b);
}

.candidate-buttons {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
  padding: 18px 20px;
}

.candidate-buttons button {
  height: 34px;
  padding: 0 12px;
  font-size: 14px;
}

.pairwiseCandidate.active {
  background: var(--accent);
  color: #fff;
}

.pairwiseCandidate:disabled {
  opacity: .45;
  cursor: not-allowed;
}

.search-panel {
  display: grid;
  grid-template-columns: 240px 1fr;
  gap: 32px;
  align-items: start;
  padding-bottom: 24px;
  border-bottom: 1px solid var(--line);
}

h1 {
  margin: 0;
  font-size: 42px;
  line-height: 1;
  letter-spacing: 0;
}

p {
  margin: 8px 0 0;
  color: var(--muted);
}

textarea {
  width: 100%;
  min-height: 128px;
  resize: vertical;
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 14px 16px;
  background: var(--panel);
  color: var(--ink);
  font: 16px/1.5 ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
}

button {
  height: 40px;
  border: 0;
  border-radius: 6px;
  padding: 0 16px;
  background: var(--accent);
  color: #fff;
  font: inherit;
  font-size: 15px;
  font-weight: 650;
  cursor: pointer;
}

button.secondary {
  background: #e9eeeb;
  color: var(--ink);
}

.go-scope-tabs button,
.go-level-tabs button,
.go-control-group button {
  height: 22px;
  min-height: 22px;
  padding: 0 7px;
  border: 1px solid var(--line);
  border-radius: 5px;
  background: #fff;
  color: var(--muted);
  font-size: 11.5px;
  font-weight: 800;
  line-height: 20px;
}

.go-control-group button.secondary {
  background: #fff;
  color: var(--muted);
}

.go-scope-tabs button.active,
.go-level-tabs button.active,
.go-control-group button.active {
  border-color: var(--accent);
  background: #e9f3ef;
  color: var(--accent);
}

.file-button {
  display: inline-flex;
  align-items: center;
  height: 40px;
  border-radius: 6px;
  padding: 0 14px;
  background: #e9eeeb;
  color: var(--ink);
  font-size: 15px;
  font-weight: 650;
  cursor: pointer;
}

.file-button input {
  display: none;
}

.similarity-meta button,
.tree-actions button,
.report-actions button {
  height: 34px;
  padding: 0 12px;
  font-size: 14px;
}

.controls {
  display: flex;
  align-items: center;
  gap: 10px;
  margin-top: 12px;
  flex-wrap: wrap;
}

.search-limit {
  color: var(--muted);
  font-size: 15px;
}

.go-input-note {
  display: grid;
  gap: 2px;
  line-height: 1.35;
}

.upload-rule {
  margin: 9px 0 0;
  color: var(--muted);
  font-size: 13px;
  line-height: 1.45;
}

.results {
  display: grid;
  gap: 18px;
  margin-top: 22px;
}

.site-footer {
  margin: 28px 0 0;
  padding-top: 18px;
  border-top: 1px solid var(--line);
  color: var(--muted);
  font-size: 13px;
}

.gene-card {
  min-width: 0;
  background: var(--panel);
  border: 1px solid var(--line);
  border-radius: 8px;
  overflow: hidden;
}

.gene-head {
  display: flex;
  justify-content: space-between;
  gap: 16px;
  padding: 18px 20px;
  border-bottom: 1px solid var(--line);
}

.gene-title {
  display: flex;
  align-items: baseline;
  gap: 12px;
  flex-wrap: wrap;
}

.gene-title h2 {
  margin: 0;
  font-size: 28px;
  letter-spacing: 0;
}

.tag {
  display: inline-flex;
  align-items: center;
  min-height: 26px;
  border: 1px solid var(--line);
  border-radius: 999px;
  padding: 0 11px;
  color: var(--muted);
  font-size: 13px;
}

.multi-panel {
  background: var(--panel);
  border: 1px solid var(--line);
  border-radius: 8px;
  overflow: hidden;
}

.multi-head {
  display: flex;
  justify-content: space-between;
  gap: 16px;
  align-items: flex-start;
  padding: 18px 20px;
  border-bottom: 1px solid var(--line);
}

.multi-head h2 {
  margin: 0;
  font-size: 30px;
  letter-spacing: 0;
}

.table-wrap {
  max-width: 100%;
  min-width: 0;
  overflow-x: auto;
}

.domainResult .table-wrap,
.similarityResult .table-wrap {
  border: 1px solid var(--line);
  border-radius: 6px;
}

.domainResult table,
.similarityResult table {
  min-width: 820px;
}


.multi-panel > .table-wrap {
  padding: 0 20px 18px;
}

.multi-panel > .note {
  margin: 12px 20px 18px;
}

.candidate-group > .table-wrap {
  padding: 0 20px 18px;
}

.candidate-group > .tree-actions,
.candidate-group > .tree,
.candidate-group > .empty,
.candidate-group > .note {
  margin-left: 20px;
  margin-right: 20px;
}

.candidate-group > .tree {
  width: calc(100% - 40px);
}

.multi-table th,
.multi-table td {
  white-space: nowrap;
}

.multi-table .query-match-cell {
  max-width: 140px;
  overflow: hidden;
  color: var(--muted);
  text-overflow: ellipsis;
}

.multi-table th:first-child,
.multi-table td:first-child {
  width: 1%;
  padding-right: 6px;
}

.multi-table tbody tr {
  cursor: default;
}

.multi-table tbody tr.active {
  background: #edf5f2;
}

.multi-table .viewReport {
  height: 26px;
  padding: 0 9px;
  border-radius: 5px;
  font-size: 12px;
  line-height: 24px;
}

.selected-report {
  display: grid;
  gap: 22px;
}

.selected-report-nav {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 12px;
  padding: 12px 14px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfcfb;
  color: var(--muted);
  font-size: 14px;
  font-weight: 800;
}

.selected-report-nav.bottom {
  justify-content: flex-start;
}

.multi-missing {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
  padding: 12px 20px 16px;
}

.error-inline {
  color: var(--accent-2);
  font-size: 13px;
}

.search-note {
  padding: 12px 14px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfcfb;
  color: var(--muted);
  font-size: 15px;
}

.sections {
  display: grid;
  grid-template-columns: 1fr;
  gap: 14px;
  min-width: 0;
  padding: 14px;
  background: #f6f8f7;
}

.block {
  min-width: 0;
  padding: 22px 22px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--panel);
}

.block h3 {
  margin: 0 0 12px;
  font-size: 19px;
  text-transform: uppercase;
  letter-spacing: .08em;
  color: var(--muted);
}

.link-button {
  height: auto;
  border: 0;
  border-radius: 0;
  padding: 0;
  background: transparent;
  color: var(--accent);
  font-weight: 780;
  text-decoration: underline;
  text-underline-offset: 3px;
}

.link-button:hover {
  color: #0b4f42;
}

.report-actions {
  display: flex;
  gap: 8px;
  flex-wrap: wrap;
  margin-bottom: 12px;
}

.kv {
  display: grid;
  grid-template-columns: 120px 1fr;
  gap: 10px 16px;
  font-size: 16px;
  line-height: 1.5;
}

.kv span:nth-child(odd) {
  color: var(--muted);
  font-weight: 800;
}

.known-silybum-block {
  display: grid;
  gap: 10px;
  margin-top: 16px;
  padding-top: 14px;
  border-top: 1px solid var(--line);
}

.known-silybum-head {
  display: grid;
  gap: 3px;
}

.known-silybum-head strong {
  color: var(--ink);
  font-size: 15px;
}

.known-silybum-head span {
  color: var(--muted);
  font-size: 13px;
  line-height: 1.45;
}

.known-silybum-table-wrap {
  max-width: 100%;
  overflow-x: auto;
  border: 1px solid var(--line);
  border-radius: 6px;
}

.known-silybum-table {
  width: 100%;
  min-width: 760px;
  border-collapse: collapse;
  background: #fff;
}

.known-silybum-table th,
.known-silybum-table td {
  padding: 7px 9px;
  border-bottom: 1px solid var(--line);
  color: var(--ink);
  font-size: 12.5px;
  line-height: 1.35;
  text-align: left;
  vertical-align: top;
}

.known-silybum-table th {
  background: #f6f8f7;
  color: var(--muted);
  font-size: 11.5px;
  font-weight: 850;
  text-transform: uppercase;
}

.known-silybum-table tr:last-child td {
  border-bottom: 0;
}

.known-silybum-table td:nth-child(2),
.known-silybum-table td:nth-child(5),
.known-silybum-table td:nth-child(6) {
  white-space: nowrap;
}

.known-silybum-table a {
  color: var(--accent);
  font-weight: 800;
}

.model {
  width: 100%;
  height: auto;
  min-height: 120px;
  border: 1px solid var(--line);
  border-radius: 6px;
  background: #fbfcfb;
}

.legend {
  display: flex;
  gap: 14px;
  flex-wrap: wrap;
  margin-top: 10px;
  color: var(--muted);
  font-size: 13px;
}

.swatch {
  display: inline-block;
  width: 12px;
  height: 12px;
  border-radius: 3px;
  margin-right: 5px;
  vertical-align: -2px;
}

.expr-controls,
.seq-controls {
  display: flex;
  gap: 10px;
  align-items: center;
  flex-wrap: wrap;
  margin-bottom: 12px;
}

select,
input[type="range"] {
  accent-color: var(--accent);
}

.chart {
  width: 100%;
  min-height: 210px;
  max-width: 760px;
}

.expr-layout {
  display: grid;
  grid-template-columns: minmax(0, 760px) minmax(260px, 1fr);
  gap: 16px;
  align-items: stretch;
}

.expr-source {
  display: grid;
  gap: 8px;
  align-content: start;
  padding: 12px 13px;
  border: 1px solid var(--line);
  border-left: 4px solid var(--accent);
  border-radius: 8px;
  background: #fbfcfb;
}

.expr-source strong {
  color: var(--ink);
  font-size: 14px;
}

.expr-source p {
  margin: 0;
  color: var(--muted);
  font-size: 12px;
  line-height: 1.35;
}

.expr-source a {
  color: var(--accent);
  font-weight: 800;
}

.expr-stage-list {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 7px;
}

.expr-stage {
  display: grid;
  grid-template-columns: 56px minmax(0, 1fr);
  gap: 7px;
  align-items: start;
  min-height: 70px;
  padding: 6px;
  border: 1px solid var(--line);
  border-radius: 7px;
  background: #fff;
}

.expr-stage img {
  width: 56px;
  aspect-ratio: 1;
  object-fit: cover;
  border-radius: 6px;
  border: 1px solid var(--line);
}

.expr-stage div {
  display: grid;
  gap: 3px;
}

.expr-stage b {
  color: var(--ink);
  font-size: 11px;
  font-weight: 850;
}

.expr-stage span {
  color: var(--muted);
  font-size: 11px;
  line-height: 1.25;
}

.expr-credit {
  padding-top: 7px;
  border-top: 1px solid var(--line);
  font-size: 10.5px;
  line-height: 1.3;
}

.expr-credit a {
  font-weight: 800;
}

.seq {
  display: block;
  width: 100%;
  min-width: 0;
  box-sizing: border-box;
  min-height: 120px;
  max-height: none;
  overflow: visible;
  white-space: pre-wrap;
  overflow-wrap: anywhere;
  word-break: break-word;
  border: 1px solid var(--line);
  border-radius: 6px;
  padding: 10px 38px 10px 10px;
  background: #fbfcfb;
  font: 13px/1.7 var(--sequence-font);
}

.seq-wrap {
  position: relative;
  min-width: 0;
  max-width: 100%;
}

.icon-button.copySequence {
  position: absolute;
  top: 8px;
  right: 8px;
  z-index: 1;
  width: 28px;
  height: 28px;
  border: 1px solid var(--line);
  border-radius: 6px;
  background: #fff;
  color: var(--accent);
  cursor: pointer;
}

.icon-button.copySequence::before,
.icon-button.copySequence::after {
  content: "";
  position: absolute;
  border: 2px solid currentColor;
  border-radius: 2px;
}

.icon-button.copySequence::before {
  width: 10px;
  height: 12px;
  left: 8px;
  top: 8px;
  background: #fff;
}

.icon-button.copySequence::after {
  width: 10px;
  height: 12px;
  left: 11px;
  top: 5px;
  background: #fff;
}

.icon-button.copySequence.copied::before {
  width: 12px;
  height: 7px;
  left: 7px;
  top: 8px;
  border-top: 0;
  border-right: 0;
  border-radius: 0;
  transform: rotate(-45deg);
  background: transparent;
}

.icon-button.copySequence.copied::after {
  display: none;
}

.seq-controls .seqRange {
  min-height: 30px;
  padding: 0 13px;
  border-radius: 7px;
  color: var(--ink);
  font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
  font-size: 14px;
  font-weight: 800;
}

.seq .cds {
  background: rgba(18, 107, 91, .24);
}

.seq .exon {
  background: rgba(158, 182, 174, .55);
}

.seq .utr {
  background: rgba(217, 164, 65, .42);
}

table {
  width: 100%;
  border-collapse: collapse;
  font-size: 15px;
}

th,
td {
  border-bottom: 1px solid var(--line);
  padding: 10px 8px;
  text-align: left;
  vertical-align: top;
}

th {
  color: var(--muted);
  font-weight: 650;
}

.empty,
.error {
  padding: 18px 20px;
  color: var(--muted);
}

.error {
  color: var(--accent-2);
}

.similarity-meta {
  display: flex;
  gap: 8px;
  flex-wrap: wrap;
  justify-content: flex-end;
  margin-bottom: 12px;
}

.subtle-id {
  color: var(--muted);
  font-size: 12px;
}

.similarity-pager {
  display: flex;
  justify-content: flex-end;
  align-items: center;
  gap: 10px;
  margin: 12px 0 16px;
  color: var(--muted);
  font-size: 13px;
  font-weight: 800;
}

.similarity-pager button {
  height: 30px;
  padding: 0 10px;
  font-size: 12px;
}

.similarity-pager button:disabled {
  opacity: .45;
  cursor: not-allowed;
}

.tree-title {
  margin-top: 20px !important;
  font-size: 19px !important;
}

.tree-actions {
  display: flex;
  justify-content: flex-end;
  gap: 8px;
  margin: 0 0 10px;
}

.tree {
  width: 100%;
  max-width: 980px;
  min-height: 220px;
  border: 1px solid var(--line);
  border-radius: 6px;
  background: #fbfcfb;
}

.domain-map {
  width: 100%;
  max-width: 980px;
  min-height: 120px;
  margin-bottom: 12px;
  border: 1px solid var(--line);
  border-radius: 6px;
  background: #fbfcfb;
}

.newick {
  margin-top: 10px;
  color: var(--muted);
  font-size: 15px;
}

.newick pre {
  white-space: pre-wrap;
  word-break: break-all;
  color: var(--ink);
}

.note {
  margin: 8px 0 12px;
  color: var(--muted);
  font-size: 13px;
}

.block h3,
.blast-hit-section h3,
.guide-result-section h3,
.primer-result-card h3,
.blast-result-card h3,
.go-category h3,
.candidate-rank-section h4,
.pair-domain-section h4,
.tree-title,
.prioritizer-results-panel h3,
.prioritizer-detail-panel h4,
.prioritizer-heatmap-panel h4,
.prioritizer-metric-panel h4 {
  color: var(--muted);
  font-size: 16px;
  font-weight: 900;
  letter-spacing: .07em;
  line-height: 1.25;
  text-transform: uppercase;
}

.multi-head h2,
.go-summary h2 {
  color: var(--ink);
  font-size: 24px;
  font-weight: 850;
  letter-spacing: 0;
  line-height: 1.25;
  text-transform: none;
}

.known-silybum-head strong,
.expr-source strong,
.gdna-head strong,
.pairwise-focus-head strong,
.go-control-group > strong,
.prioritizer-summary-kv span,
.prioritizer-subscore-heatmap span,
.prioritizer-matrix-label strong,
.prioritizer-kv span,
.prioritizer-metric-row span,
.prioritizer-model-axis strong,
.prioritizer-neighborhood-axis strong,
.prioritizer-model-legend,
.prioritizer-neighbor-list span,
.guide-summary-grid span,
.blast-summary-grid span {
  font-size: 14.5px;
  line-height: 1.35;
}

.prioritizer-heatmap-panel header span,
.prioritizer-metric-panel header span,
.go-summary header span,
.go-category header span,
.known-silybum-head span,
.expr-source p,
.prioritizer-summary-score span,
.prioritizer-summary-evidence span,
.prioritizer-matrix-label span,
.prioritizer-matrix-legend,
.prioritizer-homology-track div b,
.prioritizer-cpm-axis,
.prioritizer-cpm-boxgroup em,
.prioritizer-cpm-plot p,
.prioritizer-tau-axis,
.prioritizer-neighbor-list b {
  font-size: 13.5px;
  line-height: 1.4;
}

.block p,
.go-summary header span,
.go-category header span,
.prioritizer-results-panel header p,
.prioritizer-detail-panel p,
.guide-method-note p,
.placeholder-panel p {
  color: var(--muted);
  font-size: 14px;
  line-height: 1.55;
}

@media (max-width: 1100px) {
  .home-tools {
    width: min(980px, 100%);
    grid-template-columns: minmax(280px, .82fr) minmax(340px, 1fr);
  }

  .tool-list {
    grid-template-columns: 1fr;
    grid-template-rows: auto;
    gap: 14px;
  }

  .tool-group-browse,
  .tool-group-search,
  .tool-group-analyze {
    grid-column: auto;
    grid-row: auto;
  }

  .source-list {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }

}

@media (max-width: 820px) {
  .top-nav {
    align-items: flex-start;
    flex-direction: column;
    gap: 10px;
    padding: 10px 16px;
  }

  .nav-menu {
    width: 100%;
    overflow-x: auto;
  }

  .dropdown-menu {
    left: 0;
    right: auto;
  }

  .team-grid {
    grid-template-columns: 1fr;
  }

  .team-card {
    grid-template-columns: 1fr;
  }

  .team-card-supervisors .team-people {
    grid-template-columns: 1fr;
  }

  .team-role {
    grid-row: auto;
  }

  .source-list {
    grid-template-columns: 1fr;
  }

  .home-view {
    min-height: auto;
  }

  .home-tools {
    grid-template-columns: 1fr;
  }

  .tool-list {
    grid-template-columns: 1fr;
    gap: 14px;
  }

  .genome-view {
    width: 100%;
    margin-left: 0;
    margin-right: 0;
  }

  .home-photo {
    min-height: 260px;
  }

  .brand-line {
    gap: 10px;
  }

  .home-head h1 {
    font-size: 44px;
  }

  .home-intro {
    font-size: 15px;
    text-align: left;
  }

  .search-panel {
    grid-template-columns: 1fr;
  }

  .guide-grid {
    grid-template-columns: 1fr;
  }

  .primer-grid,
  .blast-form,
  .parameter-row {
    grid-template-columns: 1fr;
  }

  .functional-form {
    grid-template-columns: 1fr;
  }

  .prioritizer-form {
    grid-template-columns: 1fr;
  }

  .prioritizer-detail-grid,
  .prioritizer-explain-grid,
  .prioritizer-evidence-grid,
  .prioritizer-metric-grid {
    grid-template-columns: 1fr;
  }

  .prioritizer-detail-panel header {
    flex-direction: column;
  }

  .prioritizer-summary-score strong {
    font-size: 34px;
  }

  .prioritizer-subscore-row,
  .prioritizer-expression-row,
  .prioritizer-heatmap-row,
  .prioritizer-matrix-row,
  .prioritizer-go-group,
  .prioritizer-summary-layout,
  .prioritizer-summary-kv,
  .prioritizer-subscore-heatmap,
  .prioritizer-subscore-heatmap div,
  .prioritizer-expression-boxrow,
  .prioritizer-expression-axis,
  .prioritizer-metric-row {
    grid-template-columns: 1fr;
  }

  .prioritizer-expression-row b,
  .prioritizer-subscore-heatmap strong,
  .prioritizer-expression-boxrow > b,
  .prioritizer-metric-row strong,
  .prioritizer-heatmap-row em {
    text-align: left;
  }

  .prioritizer-expression-figure {
    grid-template-columns: 1fr;
  }

  .prioritizer-homology-track div {
    grid-template-columns: 1fr;
  }

  .prioritizer-homology-track div b,
  .prioritizer-expression-axis span:nth-child(2),
  .prioritizer-expression-axis span:nth-child(3) {
    text-align: left;
  }

  .prioritizer-heatmap-panel header,
  .prioritizer-metric-panel header {
    align-items: flex-start;
    flex-direction: column;
  }

  .prioritizer-heatmap-panel header span,
  .prioritizer-metric-panel header span {
    text-align: left;
  }

  .primer-seq-cell {
    min-width: 360px;
  }

  .primer-seq-cell div {
    grid-template-columns: 1fr;
  }

  .primer-track {
    width: 240px;
  }

  .expr-layout {
    grid-template-columns: 1fr;
  }

  .guide-input-panel,
  .guide-options-panel,
  .blast-input-panel,
  .blast-options-panel,
  .primer-input-panel,
  .primer-options-panel,
  .functional-input-panel,
  .functional-options-panel,
  .prioritizer-input-panel,
  .prioritizer-options-panel {
    min-height: 0;
  }

  .guide-summary-grid,
  .go-overview-grid,
  .blast-summary-grid {
    grid-template-columns: 1fr;
  }

  .go-summary header,
  .go-category header {
    flex-direction: column;
  }

  .go-section-toolbar {
    grid-template-columns: 1fr;
  }

  .placeholder-grid {
    grid-template-columns: 1fr;
  }

  .gdna-head {
    align-items: flex-start;
    flex-direction: column;
  }

  .quick-nav {
    right: 14px;
    bottom: 14px;
  }

  .quick-nav button {
    width: 76px;
    height: 34px;
    font-size: 12px;
  }

  .gene-head {
    flex-direction: column;
  }

  .known-silybum-table {
    min-width: 720px;
  }
}